盐酸奈比洛尔-那格列奈双层片治疗糖尿病和高血压的处方及体外评价。

Journal of drug delivery Pub Date : 2015-01-01 Epub Date: 2015-01-14 DOI:10.1155/2015/827859
Harika Ryakala, S Dineshmohan, Alluri Ramesh, V R M Gupta
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引用次数: 20

摘要

糖尿病(DM)和高血压是两种常见病,经常并存。糖尿病患者最常见的死因是心脏病。在本研究中,我们联合使用奈比洛尔和那格列奈,以提高患者的依从性。IR层采用交联维酮、交联纤维素钠、淀粉乙醇酸钠等多种超崩解剂配制,SR层采用HPMC E15、乙基纤维素、白胶、黄原胶等聚合物和胶配制。两层药物的崩解和溶出研究表明,表面活性剂十二烷基硫酸钠(IR)和溶出介质(SR)的加入促进了两层药物的释放。优化后的IR层(NBL8)和SR层(N9)的动力学研究表明,其线性良好,回归系数分别为0.9714 (Higuchi模型)和0.9931(零级动力学)。上述结果表明,优化后的奈比洛尔(NBL8) IR层和那格列奈德(N9) SR层可能适合于两种药物在双层片剂中序贯释放治疗糖尿病和高血压。ir -即刻释放,sr -持续释放,nbl8 -奈比洛尔8,n9 -那格列奈德9。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Formulation and in vitro evaluation of bilayer tablets of nebivolol hydrochloride and nateglinide for the treatment of diabetes and hypertension.

Formulation and in vitro evaluation of bilayer tablets of nebivolol hydrochloride and nateglinide for the treatment of diabetes and hypertension.

Formulation and in vitro evaluation of bilayer tablets of nebivolol hydrochloride and nateglinide for the treatment of diabetes and hypertension.

Formulation and in vitro evaluation of bilayer tablets of nebivolol hydrochloride and nateglinide for the treatment of diabetes and hypertension.

Diabetes mellitus (DM) and hypertension are two common diseases that often coexist. The most common cause of death in the diabetic patient is heart disease. In the present investigation we combine Nebivolol and Nateglinide for better patient compliance. IR layer was formulated using various superdisintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate and SR layer was formulated using polymers and gums like HPMC E15, ethyl cellulose, Gaur gum, and Xanthan gum. The disintegration and dissolution study of both layers showed that inclusion of surfactant (sodium lauryl sulphate) to the tablet formulation (IR) and dissolution medium (SR) enhanced the release of drugs from both layers. Kinetic studies of optimized IR layer (NBL8) and SR layer (N9) showed good linearity with regression coefficient of 0.9714 (Higuchi model) and 0.9931 (zero order kinetics), respectively. The above results reveal that the optimized IR layer of Nebivolol (NBL8) and SR layer of Nateglinide (N9) might be suitable for the treatment of diabetes and hypertension by sequential release of the two drugs in a bilayer tablet. IR-immediate release, SR-sustain release, NBL8-Nebivolol 8, N9-Nateglinide 9.

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来源期刊
Journal of drug delivery
Journal of drug delivery PHARMACOLOGY & PHARMACY-
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