Christian Bottomley, Abdoulie Bojang, Peter G Smith, Ousainou Darboe, Martin Antonio, Ebenezer Foster-Nyarko, Beate Kampmann, Brian Greenwood, Umberto D'Alessandro, Anna Roca
{"title":"儿童疫苗对鼻咽部细菌携带的影响:一项纵向研究。","authors":"Christian Bottomley, Abdoulie Bojang, Peter G Smith, Ousainou Darboe, Martin Antonio, Ebenezer Foster-Nyarko, Beate Kampmann, Brian Greenwood, Umberto D'Alessandro, Anna Roca","doi":"10.1186/s12982-014-0022-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx.</p><p><strong>Methods: </strong>A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines.</p><p><strong>Results: </strong>A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage.</p><p><strong>Conclusions: </strong>Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination.</p>","PeriodicalId":39896,"journal":{"name":"Emerging Themes in Epidemiology","volume":"12 1","pages":"1"},"PeriodicalIF":3.6000,"publicationDate":"2015-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12982-014-0022-3","citationCount":"31","resultStr":"{\"title\":\"The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study.\",\"authors\":\"Christian Bottomley, Abdoulie Bojang, Peter G Smith, Ousainou Darboe, Martin Antonio, Ebenezer Foster-Nyarko, Beate Kampmann, Brian Greenwood, Umberto D'Alessandro, Anna Roca\",\"doi\":\"10.1186/s12982-014-0022-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx.</p><p><strong>Methods: </strong>A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines.</p><p><strong>Results: </strong>A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage.</p><p><strong>Conclusions: </strong>Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination.</p>\",\"PeriodicalId\":39896,\"journal\":{\"name\":\"Emerging Themes in Epidemiology\",\"volume\":\"12 1\",\"pages\":\"1\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2015-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/s12982-014-0022-3\",\"citationCount\":\"31\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Emerging Themes in Epidemiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s12982-014-0022-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2015/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emerging Themes in Epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s12982-014-0022-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2015/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study.
Background: There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx.
Methods: A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines.
Results: A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage.
Conclusions: Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination.
期刊介绍：
Emerging Themes in Epidemiology is an open access, peer-reviewed, online journal that aims to promote debate and discussion on practical and theoretical aspects of epidemiology. Combining statistical approaches with an understanding of the biology of disease, epidemiologists seek to elucidate the social, environmental and host factors related to adverse health outcomes. Although research findings from epidemiologic studies abound in traditional public health journals, little publication space is devoted to discussion of the practical and theoretical concepts that underpin them. Because of its immediate impact on public health, an openly accessible forum is needed in the field of epidemiology to foster such discussion.
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