利用SCOP2研究蛋白质结构和进化

Q1 Biochemistry, Genetics and Molecular Biology

Current protocols in bioinformatics Pub Date : 2018-02-15 DOI:10.1002/0471250953.bi0126s49

Antonina Andreeva, Dave Howorth, Cyrus Chothia, Eugene Kulesha, Alexey G. Murzin

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引用次数: 19

摘要

SCOP2是蛋白质结构分类(SCOP)数据库的后继版本，该数据库根据结构和进化关系对已知结构的蛋白质进行组织。它的设计目的是为蛋白质分类提供一个更高级的框架。SCOP2分类是根据一个有向无环图来描述的，其中每个节点定义了一个特定类型的关系，该关系由一个蛋白质结构和序列区域表示。SCOP2数据可以通过SCOP2- browser和SCOP2- graph访问。本协议单元描述了探索和研究SCOP2进化和结构分组的不同方法。©2015 by John Wiley &儿子,Inc。

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Investigating Protein Structure and Evolution with SCOP2

SCOP2 is a successor to the Structural Classification of Proteins (SCOP) database that organizes proteins of known structure according to their structural and evolutionary relationships. It was designed to provide a more advanced framework for the classification of proteins. The SCOP2 classification is described in terms of a directed acyclic graph in which each node defines a relationship of particular type that is represented by a region of protein structure and sequence. The SCOP2 data are accessible via SCOP2-Browser and SCOP2-Graph. This protocol unit describes different ways to explore and investigate the SCOP2 evolutionary and structural groupings. © 2015 by John Wiley & Sons, Inc.

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Current protocols in bioinformatics Biochemistry, Genetics and Molecular Biology-Biochemistry

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