半乳糖凝集素-3:预防癌症的潜在靶点。

IF 0.2 Q4 Chemistry

Trends in Carbohydrate Research Pub Date : 2011-01-01

Hafiz Ahmed, Prasun Guha, Engin Kaptan, Gargi Bandyopadhyaya

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引用次数: 0

摘要

蛋白质-碳水化合物相互作用在调节细胞间和细胞外基质相互作用中发挥重要作用，从而介导多种生物过程，如生长调节、免疫功能、肿瘤转移和细胞凋亡。半乳糖凝集素-3是β-半乳糖苷结合蛋白家族的一员，被发现具有多种功能，参与正常的生长发育以及癌症的进展和转移，但其功能的详细机制尚不清楚。本文就其结构、结合特性、转录调控及其在同型/异型细胞粘附、血管生成和凋亡中的作用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Galectin-3: a potential target for cancer prevention.

Protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding protein family, is found multifunctional and is involved in normal growth development as well as cancer progression and metastasis, but the detailed mechanisms of its functions are not well understood. This review discusses its structure, binding properties, transcriptional regulation and roles in homotypic/heterotypic cell adhesion, angiogenesis and apoptosis.

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来源期刊

Trends in Carbohydrate Research CHEMISTRY, ORGANIC-

CiteScore

0.30

自引率

0.00%

发文量

期刊介绍： The overall aim of the TCR is to advance and disseminate knowledge in all related areas of carbohydrates to benefit the carbohydrate community. It offers an international forum for exchange of latest research and developments related to various scientific and technological aspects of carbohydrates and publishes original research in form of normal length research papers, short reports, review articles in the following facets lie well within the scope of this journal. 1. Carbohydrate polymers having current or potential industrial applications, their structures, properties, and modifications both chemical and microbiological. 2. Chemistry and biology of carbohydrates including synthesis, structure elucidation, stereochemistry, reaction mechanism, isolation of natural molecules, physicochemical studies, biosynthesis, metabolism, degradation, structural and functional biochemistry, enzymes- their action and mechanisms, immunochemistry, and glycobiology. 3. Analytical methods / chemistry of carbohydrates 4. Technologies for conversion or production of industrially important carbohydrates including methods, processes, and systems. The journal also publishes reports of conferences, book reviews, news items, details of forthcoming meetings and contributions describing industrial applications.