[细菌形状测定规则]。

Daisuke Shiomi
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引用次数: 0

摘要

细菌的细胞形状多样,如圆形、棒状、螺旋状等。然而,每种细菌都有自己的形状,它们的长度和宽度在一个种群中保持在一个狭窄的范围内。细胞形态异常常导致细胞死亡。因此,保持它们的形状是很重要的。杆状细菌大肠杆菌需要调节细胞的极性、长度和宽度,以形成杆状。细菌的形状是由基因调控的。特别是细菌肌动蛋白MreB及其相互作用蛋白参与调控。我们已经确定了rodZ是一种新的细胞形状决定因素,并在过去的几年里一直在分析rodZ蛋白。rodZ突变体是圆形的。我们分离了rodZ突变体的抑制突变体。抑制器的形状为棒状。通过分析rodZ突变体和抑制子,我们得出结论,rodZ有助于MreB细丝的组装。MreB参与细胞极性、长度和宽度的调控,而RodZ参与细胞长度和宽度的调控。本文就我们的研究和其他研究小组在细菌细胞形态方面的研究进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Regulation of determination of bacterial shape].

Bacteria show various cell shape such as round, rod, helical, and so on. However, each bacterium has its own shape and their length and width are kept in a narrow range in a population. Abnormal cell shape often results in death of the cells. Therefore, it is important to maintain their shape. Rod-shaped bacterium Escherichia coli needs to regulate cell polarity, length and width in order to form rod shape. Bacterial shape is genetically regulated. Especially, MreB, a bacterial actin, and its interacting proteins are involved in the regulation. We have identified rodZ as a novel cell shape determinant and have been analyzing RodZ protein in the past few years. The rodZ mutant is round. We isolated suppressor mutants of the rodZ mutant. The shape of the suppressors was rod shape. By analyzing the rodZ mutant and the suppressors, we concluded that RodZ helps assembly of MreB filaments. MreB plays roles in regulation of cell polarity, length, and width, whereas RodZ is involved in regulation of length and width. In this review, I summarize our research and research from other groups on bacterial cell shape.

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