Linda M Liao, Jonathan N Hofmann, Farin Kamangar, Paul T Strickland, Bu-Tian Ji, Gong Yang, Hong-Lan Li, Nathaniel Rothman, Wei Zheng, Wong-Ho Chow, Yu-Tang Gao, Xiao-Ou Shu
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引用次数: 0
摘要
用途:多环芳烃(PAHs)是有机物不完全燃烧的副产物。来源包括烟草烟雾、炭烤肉和空气污染。间接证据表明，多环芳烃可能与致癌有关，但与胃癌的关系尚不清楚。方法:采用巢式病例对照研究设计，我们在上海妇女健康研究中检测了153例胃癌患者和306例匹配对照者的诊断前尿1-羟基芘葡萄糖醛酸(1-OHPG)，一种多环芳烃代谢物。采用校正潜在危险因素的条件logistic回归来估计优势比(ORs)和95%置信区间(95% ci)。结果:患者尿1-OHPG浓度略高于对照组，中位数分别为0.29 μmol/mol Cr(四分位数范围0.16 ~ 0.48)和0.24 μmol/mol Cr(四分位数范围0.12 ~ 0.45)。1-OHPG浓度升高似乎与胃癌风险升高有关，但不在1-OHPG的最高类别内(Q4 vs Q1: OR = 1.4;95% ci = 0.8-2.5)。结论:我们的研究结果提示，较高浓度的1-OHPG与胃癌风险相关，但未观察到明确的剂量-反应关系。
Polycyclic aromatic hydrocarbons and risk of gastric cancer in the Shanghai Women's Health Study.
Purpose: Polycyclic aromatic hydrocarbons (PAHs) are byproducts of incomplete combustion of organic materials. Sources include tobacco smoke, charbroiled meat, and air pollution. Indirect evidence suggests that PAHs may be associated with carcinogenesis, but the association with gastric cancer is unclear.
Methods: Using a nested case-control study design, we examined prediagnostic urinary concentrations of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite, in 153 gastric cancer cases and 306 matched controls within the Shanghai Women's Health Study. Conditional logistic regression adjusted for potential risk factors was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).
Results: Urinary 1-OHPG concentrations were slightly higher among cases than controls, with medians of 0.29 μmol/mol Cr (interquartile range, 0.16-0.48) and 0.24 μmol/mol Cr (interquartile range, 0.12-0.45), respectively. Increasing concentrations of 1-OHPG appeared to be associated with elevated risk of gastric cancer, but not within the highest category of 1-OHPG (Q4 vs Q1: OR = 1.4; 95% CI = 0.8-2.5).
Conclusions: Our findings suggest that higher concentrations of 1-OHPG are related to gastric cancer risk, but no clear dose-response relationship was observed.
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