急性肾损伤和慢性肾病的肠道微生物-肾脏串扰。

Nephron Clinical Practice Pub Date : 2014-01-01 Epub Date: 2014-09-24 DOI:10.1159/000363209
Sanjeev Noel, Maria N Martina-Lingua, Samatha Bandapalle, Jennifer Pluznick, Abdel Rahim A Hamad, Daniel A Peterson, Hamid Rabb
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引用次数: 47

摘要

急性肾损伤(AKI)的病理生理学涉及多种重叠的免疫、生化和血流动力学机制,这些机制调节了初始损伤和随后修复的影响。有限但最近的实验数据显示,肠道微生物群显著影响AKI的预后。其他证据表明,慢性肾病患者和实验性AKI患者肠道微生物群发生了显著变化。在这篇综述中,我们讨论了肠道微生物群对肾脏疾病的影响的现状,肠道微生物群的免疫调节作用,以及微生物群可以改变肾脏疾病的潜在机制。我们还提出了未来的研究,以阐明肠道微生物群在肾脏疾病中的作用,并探讨肠道微生物群的修饰如何成为一种潜在的治疗工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Intestinal microbiota-kidney cross talk in acute kidney injury and chronic kidney disease.

Intestinal microbiota-kidney cross talk in acute kidney injury and chronic kidney disease.

The pathophysiology of acute kidney injury (AKI) involves multiple and overlapping immunological, biochemical, and hemodynamic mechanisms that modulate the effects of both the initial insult and the subsequent repair. Limited but recent experimental data have revealed that the intestinal microbiota significantly affects outcomes in AKI. Additional evidence shows significant changes in the intestinal microbiota in chronic kidney disease patients and in experimental AKI. In this minireview, we discuss the current status of the effect of intestinal microbiota on kidney diseases, the immunomodulatory effects of intestinal microbiota, and the potential mechanisms by which microbiota can modify kidney diseases and vice versa. We also propose future studies to clarify the role of intestinal microbiota in kidney diseases and to explore how the modification of gut microbiota may be a potential therapeutic tool.

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来源期刊
Nephron Clinical Practice
Nephron Clinical Practice 医学-泌尿学与肾脏学
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