慢性经皮雌二醇安全有效地用于冠心病患者危及生命的尿毒症出血。

Nephron Extra Pub Date : 2014-08-19 eCollection Date: 2014-05-01 DOI:10.1159/000365480

Atul Bali, John Kevin Hix, Peter Kouides

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引用次数: 4

摘要

在充分透析的患者中，尿毒症血小板功能障碍很少引起显著出血。当遇到这种情况时，由于缺乏良好的治疗方式，治疗变得复杂。雌激素用于尿毒症血小板功能障碍已有报道，但由于血管病变透析患者血栓形成事件的风险，对治疗的热情有所降低。我们报告了一位长期接受腹膜透析的冠心病患者，他复发性尿毒症继发出血，危及生命，经皮雌激素治疗安全有效地持续了24个月。

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Safe and effective use of chronic transdermal estradiol for life-threatening uremic bleeding in a patient with coronary artery disease.

Uremic platelet dysfunction rarely causes significant bleeding in adequately dialyzed patients. When encountered, the management is complicated by a lack of well-supported treatment modalities. Estrogen use in uremic platelet dysfunction has been described, but enthusiasm for the treatment has been dampened by the risk of thrombotic events in vasculopathic dialysis patients. We present a patient on long-term peritoneal dialysis with coronary disease who developed recurrent life-threatening bleeding episodes secondary to uremia, where treatment with transdermal estrogen was used safely and effectively for a 24-month period.

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来源期刊

Nephron Extra

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.