Wen-Ting Liao, Ya-Ping Ye, Yong-Jian Deng, Xiu-Wu Bian, Yan-Qing Ding
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引用次数: 0
摘要
转移性癌症干细胞(MCSCs)是指具有干细胞特性和侵袭能力的癌症细胞亚群，有助于癌症转移。骨髓间充质干细胞具有自我更新能力、多向分化、发展和/或重建癌组织的潜能。与静止的癌症干细胞相比，MCSCs能够侵入正常组织，如脉管系统，抵抗化疗和/或放射治疗，逃避免疫监视，在循环中存活并形成转移。MCSCs来源于侵袭性癌症干细胞(invasive cancer stem cells, iCSCs)，因为癌症干细胞具有可塑性，这是癌细胞异质性的特征之一。在未来的个性化癌症治疗策略中，iCSCs和mscs都是癌症转移的潜在治疗靶点。
Metastatic cancer stem cells: from the concept to therapeutics.
Metastatic cancer stem cells (MCSCs) refer to a subpopulation of cancer cells with both stem cell properties and invasion capabilities that contribute to cancer metastasis. MCSCs have capability of self-renewal, potentials of multiple differentiation and development and/or reconstruction of cancer tissues. As compared with stationary cancer stem cells, MCSCs are capable of invasion to normal tissues such as vasculatures, resistance to chemo- and/or radio-therapies, escape from immune surveillance, survival in circulation and formation of metastasis. MCSCs are derived from invasive cancer stem cells (iCSCs) due to the plasticity of cancer stem cells, which is one of the characteristics of cancer cell heterogeneity. Both stages of iCSCs and MSCSs are the potential therapeutic targets for cancer metastasis in the future strategies of personalized cancer therapy.
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