Judit Újhelyi , Zoltán Újhelyi , Andrea Szalai , János F. László , Mayella Cayasso , Miklós Vecsernyés , Róbert Pórszász
{"title":"西格列汀和维格列汀对小鼠的镇痛和抗炎作用","authors":"Judit Újhelyi , Zoltán Újhelyi , Andrea Szalai , János F. László , Mayella Cayasso , Miklós Vecsernyés , Róbert Pórszász","doi":"10.1016/j.regpep.2014.09.006","DOIUrl":null,"url":null,"abstract":"<div><p><span>To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard oil-induced ear edema, ii) neutrophil accumulation, iii) mechanical and iv) thermal touch sensitivity in complete Freund's adjuvant-induced arthritis and v) capsaicin-induced plasma extravasation in the urinary bladder. For the complete examination period in i) the dose of 10</span> <span>mg sitagliptin as well as 1–10</span> <!-->mg vildagliptin was found to significantly decrease ear edema as compared to positive control (<em>p</em> <!--><<!--> <!-->0.05, <em>n</em> <!-->=<!--> <!-->8/group). All doses of sitagliptin provided an anti-inflammatory effect <em>p</em> <!--><<!--> <!-->0.005 (<em>n</em> <!-->=<!--> <span>10/group) in test ii) and an analgesic effect in iii) except 3</span> <!-->mg. Vildagliptin was similarly effective in test ii) (<em>p</em> <!--><<!--> <!-->0.005, <em>n</em> <!-->=<!--> <!-->10/group) as sitagliptin, but it failed to affect mechanical touch sensitivity. Unlike mechanical touch sensitivity, both gliptins could beneficially act on the thermal threshold (<em>p</em> <!--><<!--> <!-->0.05, <em>n</em> <!-->=<!--> <!-->10/group). And only in tests v) could both gliptins reverse inflammation. Further studies are needed to support the suggestion that the utilization of these beneficial effects of gliptins may be considered in the treatment of Type 2 diabetic patients.</p></div>","PeriodicalId":20853,"journal":{"name":"Regulatory Peptides","volume":"194 ","pages":"Pages 23-29"},"PeriodicalIF":0.0000,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.regpep.2014.09.006","citationCount":"15","resultStr":"{\"title\":\"Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice\",\"authors\":\"Judit Újhelyi , Zoltán Újhelyi , Andrea Szalai , János F. László , Mayella Cayasso , Miklós Vecsernyés , Róbert Pórszász\",\"doi\":\"10.1016/j.regpep.2014.09.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard oil-induced ear edema, ii) neutrophil accumulation, iii) mechanical and iv) thermal touch sensitivity in complete Freund's adjuvant-induced arthritis and v) capsaicin-induced plasma extravasation in the urinary bladder. For the complete examination period in i) the dose of 10</span> <span>mg sitagliptin as well as 1–10</span> <!-->mg vildagliptin was found to significantly decrease ear edema as compared to positive control (<em>p</em> <!--><<!--> <!-->0.05, <em>n</em> <!-->=<!--> <!-->8/group). All doses of sitagliptin provided an anti-inflammatory effect <em>p</em> <!--><<!--> <!-->0.005 (<em>n</em> <!-->=<!--> <span>10/group) in test ii) and an analgesic effect in iii) except 3</span> <!-->mg. Vildagliptin was similarly effective in test ii) (<em>p</em> <!--><<!--> <!-->0.005, <em>n</em> <!-->=<!--> <!-->10/group) as sitagliptin, but it failed to affect mechanical touch sensitivity. Unlike mechanical touch sensitivity, both gliptins could beneficially act on the thermal threshold (<em>p</em> <!--><<!--> <!-->0.05, <em>n</em> <!-->=<!--> <!-->10/group). And only in tests v) could both gliptins reverse inflammation. Further studies are needed to support the suggestion that the utilization of these beneficial effects of gliptins may be considered in the treatment of Type 2 diabetic patients.</p></div>\",\"PeriodicalId\":20853,\"journal\":{\"name\":\"Regulatory Peptides\",\"volume\":\"194 \",\"pages\":\"Pages 23-29\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.regpep.2014.09.006\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Regulatory Peptides\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167011514000718\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Regulatory Peptides","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167011514000718","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
摘要
为了验证西他汀和维格列汀潜在的抗炎和镇痛作用,在小鼠中使用了五种不同的实验模型:1)芥菜油诱导的耳水肿,2)中性粒细胞积聚,3)机械性和4)完全弗氏佐剂诱导的关节炎的热触摸敏感性,5)辣椒素诱导的膀胱血浆外渗。在i)的整个检查期间,与阳性对照相比,10 mg西格列汀和1-10 mg维格列汀的剂量显著减少了耳部水肿(p <0.05, n = 8/组)。所有剂量的西格列汀均具有抗炎作用p <试验ii中0.005 (n = 10/组),试验iii中除3mg外无镇痛作用。维格列汀在试验ii中同样有效(p <0.005, n = 10/组)与西格列汀相同,但对机械触摸灵敏度没有影响。与机械触觉灵敏度不同,这两种闪烁都可以对热阈值(p <0.05, n = 10/组)。只有在试验中,这两种药物才能逆转炎症。在2型糖尿病患者的治疗中,可以考虑利用格列汀的这些有益作用,这一建议需要进一步的研究来支持。
Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice
To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard oil-induced ear edema, ii) neutrophil accumulation, iii) mechanical and iv) thermal touch sensitivity in complete Freund's adjuvant-induced arthritis and v) capsaicin-induced plasma extravasation in the urinary bladder. For the complete examination period in i) the dose of 10mg sitagliptin as well as 1–10 mg vildagliptin was found to significantly decrease ear edema as compared to positive control (p < 0.05, n = 8/group). All doses of sitagliptin provided an anti-inflammatory effect p < 0.005 (n = 10/group) in test ii) and an analgesic effect in iii) except 3 mg. Vildagliptin was similarly effective in test ii) (p < 0.005, n = 10/group) as sitagliptin, but it failed to affect mechanical touch sensitivity. Unlike mechanical touch sensitivity, both gliptins could beneficially act on the thermal threshold (p < 0.05, n = 10/group). And only in tests v) could both gliptins reverse inflammation. Further studies are needed to support the suggestion that the utilization of these beneficial effects of gliptins may be considered in the treatment of Type 2 diabetic patients.
期刊介绍:
Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.