Alan Peralta-Ramírez, Ana Isabel Raya, Carmen Pineda, Mariano Rodríguez, Escolástico Aguilera-Tejero, Ignacio López
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引用次数: 4
摘要
背景/目的:血管钙化(VC)是人类和动物慢性肾脏疾病(CKD)的主要并发症，受酸碱平衡变化的影响。本研究的目的是描述患有VC的尿毒症大鼠的酸碱平衡，并将定义酸碱平衡的参数与VC相关联。方法:以5/6肾切除术(5/6 Nx)致CKD大鼠22只和非尿毒症对照组10只为研究对象。结果:5/6 Nx大鼠主动脉钙(9.2±1.7 mg/g组织)和磷(20.6±4.9 mg/g组织)含量高，VC分布广泛。由于呼吸(PaCO2 = 28.4±2.1 mm Hg)和代谢(碱过量= 4.1±1 mmol/l)紊乱，尿毒症大鼠的pH值升高(7.57±0.03)。阴离子间隙(AG)和强离子差(SID)与主动脉钙呈高度正相关(AG: r = 0.604, p = 0.02;SID: r = 0.647, p = 0.01)与主动脉磷(AG: r = 0.684, p = 0.007;SID: r = 0.785, p = 0.01)。结论:在尿毒症大鼠实验模型中，VC与AG、SID呈高度正相关。
Acid-base balance in uremic rats with vascular calcification.
Background/aims: Vascular calcification (VC), a major complication in humans and animals with chronic kidney disease (CKD), is influenced by changes in acid-base balance. The purpose of this study was to describe the acid-base balance in uremic rats with VC and to correlate the parameters that define acid-base equilibrium with VC.
Methods: Twenty-two rats with CKD induced by 5/6 nephrectomy (5/6 Nx) and 10 nonuremic control rats were studied.
Results: The 5/6 Nx rats showed extensive VC as evidenced by a high aortic calcium (9.2 ± 1.7 mg/g of tissue) and phosphorus (20.6 ± 4.9 mg/g of tissue) content. Uremic rats had an increased pH level (7.57 ± 0.03) as a consequence of both respiratory (PaCO2 = 28.4 ± 2.1 mm Hg) and, to a lesser degree, metabolic (base excess = 4.1 ± 1 mmol/l) derangements. A high positive correlation between both anion gap (AG) and strong ion difference (SID) with aortic calcium (AG: r = 0.604, p = 0.02; SID: r = 0.647, p = 0.01) and with aortic phosphorus (AG: r = 0.684, p = 0.007; SID: r = 0.785, p = 0.01) was detected.
Conclusions: In an experimental model of uremic rats, VC showed high positive correlation with AG and SID.
期刊介绍：
An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.
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