stat3通路刺激下卵巢癌进展的多尺度药物模型。

Pub Date : 2014-01-01 DOI:10.1504/ijdmb.2014.060050

Le Zhang, Yao Xue, Beini Jiang, Costas Strouthos, Zhenfeng Duan, Yukun Wu, Jing Su, Xiaobo Zhou

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引用次数: 7

摘要

本研究旨在通过转录3 (STAT 3)通路的信号转导和激活因子模拟卵巢癌的进展。主要研究STAT 3通路在白细胞介素-6 (interleukin-6, IL-6)细胞因子及多种众所周知的微观因子的刺激下，如何影响癌细胞的生物力学表型。模拟结果与最近的实验证据一致，即STAT 3通路受到刺激的卵巢癌细胞具有高存活率和耐药性。我们讨论了il - 6和这些众所周知的微观因素是如何影响癌症进展的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Multiscale agent-based modelling of ovarian cancer progression under the stimulation of the STAT 3 pathway.

This research is developed to simulate ovarian cancer progression with signal transducers and activators of the transcription 3 (STAT 3) pathway. The main focus is on studying how the STAT 3 pathway affects the cancer cells' biomechanical phenotype under the stimulation of the interleukin-6 (IL-6) cytokine and various well-known microscopic factors. The simulated results agreed with recent experimental evidence that ovarian cancer cells with a stimulated STAT 3 pathway have high survival rates and drug resistance. And we discussed how the IL6 and these well-known microscopic factors impacted the cancer progression.

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