当基因组完整性和细胞周期决定发生冲突:polo激酶在细胞适应DNA损伤中的作用。

Systems and Synthetic Biology Pub Date : 2014-09-01 Epub Date: 2014-07-27 DOI:10.1007/s11693-014-9151-9
Diego Serrano, Damien D'Amours
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引用次数: 24

摘要

繁殖的动力和保持基因组完整性的需要是作用于生物系统的两种最强大的力量。当这些力量发生冲突时,例如在细胞经历DNA损伤的情况下,反馈机制被激活,以确保细胞增殖被停止,并且在细胞修复其染色体损伤时不会引入进一步的损伤。在这种情况下,DNA损伤反应主导了增殖的生物驱动,如果损伤不能有效修复,甚至可能导致程序性细胞死亡。有趣的是,在特定条件下,增殖的驱动力可以克服DNA损伤反应,并导致检查点阻滞细胞中增殖程序的重新激活。这种现象被称为对DNA损伤的适应,在所有研究过这一过程的真核生物物种中都能观察到,包括人类的正常细胞和癌细胞。polo样激酶(Polo-like kinase, PLKs)是DNA损伤适应性反应的关键调控因子,在细胞周期和细胞检查点相关决策中起关键作用。在这里,我们回顾了最近在定义plk在适应过程中的具体作用方面的进展,以及这个保守的真核激酶家族如何将保持基因组完整性和有效细胞增殖的基本需求结合起来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage.

When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage.

When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage.

The drive to proliferate and the need to maintain genome integrity are two of the most powerful forces acting on biological systems. When these forces enter in conflict, such as in the case of cells experiencing DNA damage, feedback mechanisms are activated to ensure that cellular proliferation is stopped and no further damage is introduced while cells repair their chromosomal lesions. In this circumstance, the DNA damage response dominates over the biological drive to proliferate, and may even result in programmed cell death if the damage cannot be repaired efficiently. Interestingly, the drive to proliferate can under specific conditions overcome the DNA damage response and lead to a reactivation of the proliferative program in checkpoint-arrested cells. This phenomenon is known as adaptation to DNA damage and is observed in all eukaryotic species where the process has been studied, including normal and cancer cells in humans. Polo-like kinases (PLKs) are critical regulators of the adaptation response to DNA damage and they play key roles at the interface of cell cycle and checkpoint-related decisions in cells. Here, we review recent progress in defining the specific roles of PLKs in the adaptation process and how this conserved family of eukaryotic kinases can integrate the fundamental need to preserve genomic integrity with effective cellular proliferation.

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