万古霉素最低抑制浓度高与甲氧西林敏感金黄色葡萄球菌菌血症患者预后不良相关,无论治疗方法如何。

Juan José Castón, Francisco González-Gasca, Lourdes Porras, Soledad Illescas, Maria Dolores Romero, Julio Gijón
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引用次数: 14

摘要

我们回顾性研究了高万古霉素最低抑菌浓度(MIC > 2 μg/ml)对53例甲氧西林敏感金黄色葡萄球菌(MSSA)所致菌血症的影响。采用微量肉汤稀释法测定万古霉素MIC。主要终点为自首次血培养阳性之日起30天的全因死亡率。死亡率为22.6%(53例中有12例)。万古霉素MIC高(优势比(OR) = 9.3;95%置信区间(95% CI) = 1.31-63.20;p = 0.027), Charlson合并症指数≥3 (OR = 10.3;95% ci = 1.3-102.04;p = 0.03)、高龄(OR = 35.8;95% ci = 2.3-659.2;p = 0.01),严重脓毒症(OR = 8.5;95% ci = 1.2-61.4;P = 0.03)与死亡率相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High vancomycin minimum inhibitory concentration is associated with poor outcome in patients with methicillin-susceptible Staphylococcus aureus bacteremia regardless of treatment.

We retrospectively investigated the impact of high vancomycin minimum inhibitory concentration (MIC > 2 μg/ml) on the outcome of 53 patients with bacteremia caused by methicillin-susceptible Staphylococcus aureus (MSSA). Vancomycin MIC was determined by broth microdilution according to CLSI methods. The primary outcome was 30-day all-cause mortality from the date of the first positive blood culture. The mortality rate was 22.6% (12 of 53 patients). High vancomycin MIC (odds ratio (OR) = 9.3; 95% confidence interval (95% CI) = 1.31-63.20; p = 0.027), Charlson comorbidity index ≥ 3 (OR = 10.3; 95% CI = 1.3-102.04; p = 0.03), advanced age (OR = 35.8; 95% CI = 2.3-659.2; p = 0.01), and severe sepsis (OR = 8.5; 95% CI = 1.2-61.4; p = 0.03) were associated with mortality.

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