老年鼠斑疹伤寒49例的前瞻性研究。

Constantinos Tsioutis, George Chaliotis, Sofia Kokkini, Stephanos Doukakis, Yannis Tselentis, Anna Psaroulaki, Achilleas Gikas
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引用次数: 18

摘要

背景:老年患者伤寒立克次体感染的特点在文献中还没有广泛的描述。方法:我们对希腊两个流行区> 65岁的鼠斑疹伤寒患者进行了前瞻性研究。结果:共纳入49例老年患者,其中男性30例,占61.2%。63%的患者出现发热(100%)、头痛(83.7%)和皮疹(73.5%)的临床三联征,而不适(85.7%)、厌食(65.3%)和肌痛(59.2%)也很常见。常见的实验室检查结果为转氨血症(89.8%)、乳酸脱氢酶升高(65.3%)、血尿(55.1%)、血小板减少(53.1%)、贫血(51%)、白细胞减少(40.8%)和轻度低钠血症(23.5%)。16例(32.7%)出现并发症;没有死亡记录。结论:老年鼠斑疹伤寒的主要临床和实验室特征与青年鼠相似。然而,老年患者的临床症状更为严重,即使接受适当治疗,并发症发生率较高,发烧持续时间较长。据我们所知,这是第一个在老年人群中关注鼠斑疹伤寒的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Murine typhus in elderly patients: a prospective study of 49 patients.

Background: The characteristics of Rickettsia typhi infection in elderly patients have not been extensively described in the literature.

Methods: We conducted a prospective study on murine typhus in patients > 65 years old in two endemic areas of Greece.

Results: Forty-nine elderly patients were analyzed, including 30 (61.2%) males. The clinical triad of fever (100% of patients), headache (83.7%), and rash (73.5%), occurred in 63% of patients, whereas malaise (85.7%), anorexia (65.3%), and myalgia (59.2%) were also common. Frequent laboratory findings were transaminasemia (89.8%), lactate dehydrogenase elevation (65.3%), hematuria (55.1%), thrombocytopenia (53.1%), anemia (51%), leucopenia (40.8%), and mild hyponatremia (23.5%). Complications developed in 16 patients (32.7%); no deaths were recorded.

Conclusions: The main clinical and laboratory characteristics of murine typhus are similar in elderly and younger adults. However, elderly patients have a more severe clinical picture, evidenced by a higher complication rate and longer duration of fever, even with appropriate treatment. To our knowledge, this is the first study to focus on murine typhus in a geriatric population.

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