噬菌体行为生态学:噬菌体如何改变细菌宿主的习性?

Bacteriophage Pub Date : 2014-07-08 eCollection Date: 2014-01-01 DOI:10.4161/bact.29866
Katherine R Hargreaves, Andrew M Kropinski, Martha Rj Clokie
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引用次数: 0

摘要

噬菌体有一套重要的基因,使其能够入侵、复制和生产。除了这个 "核心 "基因组外,它们还能携带 "附属 "基因,这些基因能极大地影响细菌的生物学特性,并可能提高它们自身的成功率。噬菌体基因组的内容不断给我们带来惊喜,揭示了病毒影响细菌生物学的新方式。艰难梭菌肌病毒 phiCDHM1 的基因组包含三个细菌附属基因调节器(agr)基因的同源物。agr 系统是一种法定量感应(QS),噬菌体可通过它改变艰难梭菌与环境的相互作用。虽然它们的作用机制尚不清楚,但这些基因的细菌版本突变体会影响孢子和毒力。为了探索噬菌体的 QS 基因如何影响艰难梭菌的生物学特性,我们研究了噬菌体已被证明能影响细菌行为的主要类别,并讨论了通过 QS 的相互作用如何在更广泛的层面上影响细菌的行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Bacteriophage behavioral ecology: How phages alter their bacterial host's habits.

Bacteriophage behavioral ecology: How phages alter their bacterial host's habits.

Bacteriophage behavioral ecology: How phages alter their bacterial host's habits.

Bacteriophages have an essential gene kit that enables their invasion, replication, and production. In addition to this "core" genome, they can carry "accessory" genes that dramatically impact bacterial biology, and presumably boost their own success. The content of phage genomes continue to surprise us by revealing new ways that viruses impact bacterial biology. The genome of a Clostridium difficile myovirus, phiCDHM1, contains homologs of three bacterial accessory gene regulator (agr) genes. The agr system is a type of quorum sensing (QS), via which the phage may modify C. difficile interactions with its environment. Although their mechanism of action is unknown, mutants in bacterial versions of these genes impact sporulation and virulence. To explore how phage QS genes may influence C. difficile biology, we examine the main categories of bacterial behavior that phages have been shown to influence and discuss how interactions via QS could influence behavior at a wider level.

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