肥胖的代谢异质性:脂肪组织的作用。

International journal of obesity supplements Pub Date : 2012-07-01 DOI:10.1038/ijosup.2012.3

T McLaughlin

{"title":"肥胖的代谢异质性:脂肪组织的作用。","authors":"T McLaughlin","doi":"10.1038/ijosup.2012.3","DOIUrl":null,"url":null,"abstract":"Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogenesis as leading theories as to why excess body weight has the potential to promote insulin resistance.","PeriodicalId":14202,"journal":{"name":"International journal of obesity supplements","volume":"2 Suppl 1","pages":"S8-S10"},"PeriodicalIF":0.0000,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ijosup.2012.3","citationCount":"10","resultStr":"{\"title\":\"Metabolic heterogeneity of obesity: role of adipose tissue.\",\"authors\":\"T McLaughlin\",\"doi\":\"10.1038/ijosup.2012.3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogenesis as leading theories as to why excess body weight has the potential to promote insulin resistance.\",\"PeriodicalId\":14202,\"journal\":{\"name\":\"International journal of obesity supplements\",\"volume\":\"2 Suppl 1\",\"pages\":\"S8-S10\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1038/ijosup.2012.3\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of obesity supplements\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/ijosup.2012.3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of obesity supplements","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/ijosup.2012.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 10

摘要

肥胖并不是胰岛素抵抗的同义词。为什么有些人(而不是所有人)在体重超标的情况下会产生胰岛素抵抗，目前还不清楚，但现在有一些合理的假设得到了充分的支持。本文综述了区域脂肪分布、炎症、脂肪毒性/异位脂肪和脂肪生成受损作为超重可能促进胰岛素抵抗的主要理论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Metabolic heterogeneity of obesity: role of adipose tissue.

Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogenesis as leading theories as to why excess body weight has the potential to promote insulin resistance.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International journal of obesity supplements

自引率

0.00%

发文量