Lik Thai Lim, Yanhong Gong, Elliott Y Ah-Kee, Gexin Xiao, Xiulan Zhang, Shicheng Yu
{"title":"父母近视史对中国大陆学龄儿童近视发展的影响。","authors":"Lik Thai Lim, Yanhong Gong, Elliott Y Ah-Kee, Gexin Xiao, Xiulan Zhang, Shicheng Yu","doi":"10.4137/OED.S16031","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Myopia is a very common condition and a significant public health problem in China. The objective of the study was to explore the genetic influence on myopia in Mainland China school-aged children in Beijing.</p><p><strong>Methods: </strong>In 2008, the data from 15,316 Chinese school students aged 6-18 years from 19 randomized schools in Beijing were analyzed to evaluate genetic influence on myopia in children. Heritability was calculated by mid-parent-offspring regression and parent-offspring regression.</p><p><strong>Results: </strong>The estimate of heritability was 0.30 (95% CI, 0.27-0.33) for refractive value (RV). The adjusted mean refractive error was -2.33D (95% CI, -2.45 to -2.21) in children with two myopic parents compared with -1.13D (95% CI, -1.78 to -1.08) in children with no parental myopia. The adjusted odds ratio (OR) was 2.83 (95% CI, 2.47-3.24) in children with two myopic parents compared with no parental myopia.</p><p><strong>Conclusion: </strong>The study found a strong association between parental history of myopia and genesis of myopia in the offspring even after adjusting for environmental factors.</p>","PeriodicalId":74362,"journal":{"name":"Ophthalmology and eye diseases","volume":"6 ","pages":"31-5"},"PeriodicalIF":0.0000,"publicationDate":"2014-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/OED.S16031","citationCount":"31","resultStr":"{\"title\":\"Impact of parental history of myopia on the development of myopia in mainland china school-aged children.\",\"authors\":\"Lik Thai Lim, Yanhong Gong, Elliott Y Ah-Kee, Gexin Xiao, Xiulan Zhang, Shicheng Yu\",\"doi\":\"10.4137/OED.S16031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Myopia is a very common condition and a significant public health problem in China. The objective of the study was to explore the genetic influence on myopia in Mainland China school-aged children in Beijing.</p><p><strong>Methods: </strong>In 2008, the data from 15,316 Chinese school students aged 6-18 years from 19 randomized schools in Beijing were analyzed to evaluate genetic influence on myopia in children. Heritability was calculated by mid-parent-offspring regression and parent-offspring regression.</p><p><strong>Results: </strong>The estimate of heritability was 0.30 (95% CI, 0.27-0.33) for refractive value (RV). The adjusted mean refractive error was -2.33D (95% CI, -2.45 to -2.21) in children with two myopic parents compared with -1.13D (95% CI, -1.78 to -1.08) in children with no parental myopia. The adjusted odds ratio (OR) was 2.83 (95% CI, 2.47-3.24) in children with two myopic parents compared with no parental myopia.</p><p><strong>Conclusion: </strong>The study found a strong association between parental history of myopia and genesis of myopia in the offspring even after adjusting for environmental factors.</p>\",\"PeriodicalId\":74362,\"journal\":{\"name\":\"Ophthalmology and eye diseases\",\"volume\":\"6 \",\"pages\":\"31-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4137/OED.S16031\",\"citationCount\":\"31\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmology and eye diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4137/OED.S16031\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2014/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmology and eye diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4137/OED.S16031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2014/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Impact of parental history of myopia on the development of myopia in mainland china school-aged children.
Background: Myopia is a very common condition and a significant public health problem in China. The objective of the study was to explore the genetic influence on myopia in Mainland China school-aged children in Beijing.
Methods: In 2008, the data from 15,316 Chinese school students aged 6-18 years from 19 randomized schools in Beijing were analyzed to evaluate genetic influence on myopia in children. Heritability was calculated by mid-parent-offspring regression and parent-offspring regression.
Results: The estimate of heritability was 0.30 (95% CI, 0.27-0.33) for refractive value (RV). The adjusted mean refractive error was -2.33D (95% CI, -2.45 to -2.21) in children with two myopic parents compared with -1.13D (95% CI, -1.78 to -1.08) in children with no parental myopia. The adjusted odds ratio (OR) was 2.83 (95% CI, 2.47-3.24) in children with two myopic parents compared with no parental myopia.
Conclusion: The study found a strong association between parental history of myopia and genesis of myopia in the offspring even after adjusting for environmental factors.
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