耐力运动员上呼吸道症状患病率及口腔-呼吸道黏膜免疫的性别差异。

IF 3.5 4区 医学 Q2 IMMUNOLOGY
Exercise Immunology Review Pub Date : 2014-01-01
Cheng-Shiun He, Nicolette C Bishop, Michal K Handzlik, Ayu S Muhamad, Michael Gleeson
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引用次数: 0

摘要

本研究的目的是研究在为期16周的冬季训练期间,耐力运动员口腔-呼吸粘膜免疫的性别差异以及上呼吸道症状(URS)发作的发生率、严重程度和持续时间。在研究开始和结束时收集了210名受试者(147名男性和63名女性)的血液,以确定白细胞计数的差异。在研究开始时和研究期间每隔4周采集一次未受刺激的唾液。分析唾液样本中的抗菌肽和抗菌蛋白(AMPs)。每周培训和每日疾病记录使用有效的问卷。训练负荷平均为11小时/周的中等强度体力活动,在男性和女性之间没有差异。男性唾液溶菌酶和乳铁蛋白浓度显著高于女性(P均< 0.04),而唾液免疫球蛋白A (SIgA)和淀粉酶浓度不显著高于女性。雄鼠唾液流量显著高于雌鼠(P < 0.03),溶菌酶、乳铁蛋白和淀粉酶分泌率显著高于雌鼠(P < 0.01), SIgA分泌率不显著(P = 0.097)。血液白细胞总数、单核细胞总数和淋巴细胞总数在两性之间无显著差异,但女性的循环中性粒细胞数量较高(P = 0.040)。男性平均尿路发作次数为0.6 +/- 0.8次(平均+/- SD),女性平均尿路发作次数为0.8 +/- 1.0次(P = 0.103),女性尿路发作天数较高(4.7 vs 6.8天,P < 0.02)。女性尿潴留发作时间更长(11.6天vs 15.5天,P < 0.03)。这项研究的结果与最近关于大型竞技比赛中疾病发病率的报告一致,表明女运动员可能比男运动员更容易患尿路综合征,而较低的口腔呼吸粘膜免疫力可能是部分原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex differences in upper respiratory symptoms prevalence and oral-respiratory mucosal immunity in endurance athletes.

The purpose of this study was to examine sex differences in oral-respiratory mucosal immunity and the incidence, severity and duration of upper respiratory symptoms (URS) episodes in endurance athletes during a 16-week winter training period. Blood was collected from 210 subjects (147 men and 63 women) at the start and end of the study for determination of differential leukocyte counts. Timed collections of unstimulated saliva were obtained at the start and at 4-week intervals during the study period. Saliva samples were analysed for salivary antimicrobial peptides and proteins (AMPs). Weekly training and daily illness logs were kept using validated questionnaires. Training loads averaged 11 h/week of moderate-vigorous physical activity and were not different for males and females. The salivary concentration of lysozyme and lactoferrin (both P < 0.04) but not salivary immunoglobulin A (SIgA) or amylase were higher in males than females. Saliva flow rates were significantly higher in males than females (P < 0.03) and consequently so were the salivary secretion rates of lysozyme, lactoferrin and amylase (all P < 0.01) but not SIgA (P = 0.097). Total blood leukocyte, monocyte and lymphocyte counts were not different between the sexes but females had higher numbers of circulating neutrophils (P = 0.040). The average number of URS episodes was 0.6 +/- 0.8 (mean +/- SD) in males and 0.8 +/- 1.0 in females (P = 0.103) and the number of URS days was higher in females (4.7 vs 6.8 days, P < 0.02). The duration of URS episodes was longer in females (11.6 vs 15.5 days, P < 0.03). The findings of this study concur with recent reports of illness incidence at major competitive games indicating that female athletes may be more susceptible than their male counterparts to URS and that lower oral-respiratory mucosal immunity may, in part, account for this.

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来源期刊
Exercise Immunology Review
Exercise Immunology Review 医学-免疫学
CiteScore
16.00
自引率
0.00%
发文量
7
期刊介绍: Exercise Immunology Review (EIR) serves as the official publication of the International Society of Exercise and Immunology and the German Society of Sports Medicine and Prevention. It is dedicated to advancing knowledge in all areas of immunology relevant to acute exercise and regular physical activity. EIR publishes review articles and papers containing new, original data along with extensive review-like discussions. Recognizing the diverse disciplines contributing to the understanding of immune function, the journal adopts an interdisciplinary approach, facilitating the dissemination of research findings from fields such as exercise sciences, medicine, immunology, physiology, behavioral science, endocrinology, pharmacology, and psychology.
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