辣椒素为基础的疼痛控制疗法。

Howard Smith, John R Brooks
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引用次数: 46

摘要

已知TRPV1受体在多器官系统的伤害性传递中发挥作用,通常是对炎症疼痛的反应。迄今为止,TRPV1拮抗剂在抗痛觉方面的作用有限。辣椒素,一种TRPV1激动剂,已被证明在表达TRPV1的神经末梢诱导一个不应期,甚至在足够的剂量下,造成长期的神经末梢失能。这导致了对局部辣椒素作为治疗多种疼痛状况的研究。大部分工作集中在肌肉骨骼疼痛和神经性疼痛上,并揭示了尽管低剂量局部辣椒素作为镇痛药的效果有限,但高剂量辣椒素在耐受的情况下,对某些类型的神经性疼痛具有长期镇痛的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Capsaicin-based therapies for pain control.

The TRPV1 receptor is known to play a role in nociceptive transmission in multiple organ systems, usually in response to the pain of inflammation. TRPV1 antagonism has so far shown limited benefit in antinociception. Capsaicin, a TRPV1 agonist, has been shown to induce a refractory period in the nerve terminal expressing TRPV1 and even, in sufficient dosing, to create long-term nerve terminal defunctionalization. This has led to research into topical capsaicin as a treatment for multiple painful conditions. The majority of work has focused on musculoskeletal pain and neuropathic pain and has revealed that although low-dose topical capsaicin has limited effectiveness as an analgesic, high-dose capsaicin, when tolerated, has the potential for long-term analgesia in certain types of neuropathic pain.

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