Jamie H Choi, Louise M Ryan, Daniel W Cramer, Mark D Hornstein, Stacey A Missmer
{"title":"女性和男性摄入咖啡因对体外受精结果的影响。","authors":"Jamie H Choi, Louise M Ryan, Daniel W Cramer, Mark D Hornstein, Stacey A Missmer","doi":"10.1089/jcr.2011.0001","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to estimate the association between caffeine consumption and <i>in vitro</i> fertilization (IVF) outcomes.</p><p><strong>Methods: </strong>A total of 2474 couples were prospectively enrolled prior to undergoing their first cycle of IVF, contributing a total of 4716 IVF cycles. Discrete survival analysis adjusting for observed confounders was applied to quantify the relation between caffeine consumption and livebirth. Secondary outcomes of interest were oocyte retrieval, peak estradiol level, implantation rate, and fertilization rate.</p><p><strong>Results: </strong>Overall, caffeine consumption by women was not significantly associated with livebirth (<i>p</i><sub>trend</sub>=0.74). Compared with women who do not drink caffeine, the likelihood of livebirth was not significantly different for women who drank low (>0-800 mg/week; odds ratio [OR]=1.00, 95% confidence interval [CI])=0.83-1.21), moderate (>800-1400 mg/week; OR=0.89, 95% CI=0.71-1.12), or high levels of caffeine (>1400 mg/week; OR=1.07, 95% CI=0.85-1.34). Greater caffeine intake by women was associated with a significantly lower peak estradiol level (<i>p</i><sub>trend</sub>=0.03), but was not associated with the number of oocytes retrieved (<i>p</i><sub>trend</sub>=0.75), fertilization rate (<i>p</i><sub>trend</sub>=0.10), or implantation rate (<i>p</i><sub>trend</sub>=0.23). There was no significant association between caffeine intake by men and livebirth (<i>p</i><sub>trend</sub>=0.27), fertilization (<i>p</i><sub>trend</sub>=0.72), or implantation (<i>p</i><sub>trend</sub>=0.24). The individual effects of consumption of coffee, tea, or soda by women or men were not related to livebirth.</p><p><strong>Conclusion: </strong>Caffeine consumption by women or men was not associated with IVF outcomes.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"1 1","pages":"29-34"},"PeriodicalIF":0.0000,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2011.0001","citationCount":"29","resultStr":"{\"title\":\"Effects of Caffeine Consumption by Women and Men on the Outcome of <i>In Vitro</i> Fertilization.\",\"authors\":\"Jamie H Choi, Louise M Ryan, Daniel W Cramer, Mark D Hornstein, Stacey A Missmer\",\"doi\":\"10.1089/jcr.2011.0001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The objective of this study was to estimate the association between caffeine consumption and <i>in vitro</i> fertilization (IVF) outcomes.</p><p><strong>Methods: </strong>A total of 2474 couples were prospectively enrolled prior to undergoing their first cycle of IVF, contributing a total of 4716 IVF cycles. Discrete survival analysis adjusting for observed confounders was applied to quantify the relation between caffeine consumption and livebirth. Secondary outcomes of interest were oocyte retrieval, peak estradiol level, implantation rate, and fertilization rate.</p><p><strong>Results: </strong>Overall, caffeine consumption by women was not significantly associated with livebirth (<i>p</i><sub>trend</sub>=0.74). Compared with women who do not drink caffeine, the likelihood of livebirth was not significantly different for women who drank low (>0-800 mg/week; odds ratio [OR]=1.00, 95% confidence interval [CI])=0.83-1.21), moderate (>800-1400 mg/week; OR=0.89, 95% CI=0.71-1.12), or high levels of caffeine (>1400 mg/week; OR=1.07, 95% CI=0.85-1.34). Greater caffeine intake by women was associated with a significantly lower peak estradiol level (<i>p</i><sub>trend</sub>=0.03), but was not associated with the number of oocytes retrieved (<i>p</i><sub>trend</sub>=0.75), fertilization rate (<i>p</i><sub>trend</sub>=0.10), or implantation rate (<i>p</i><sub>trend</sub>=0.23). There was no significant association between caffeine intake by men and livebirth (<i>p</i><sub>trend</sub>=0.27), fertilization (<i>p</i><sub>trend</sub>=0.72), or implantation (<i>p</i><sub>trend</sub>=0.24). The individual effects of consumption of coffee, tea, or soda by women or men were not related to livebirth.</p><p><strong>Conclusion: </strong>Caffeine consumption by women or men was not associated with IVF outcomes.</p>\",\"PeriodicalId\":89685,\"journal\":{\"name\":\"Journal of caffeine research\",\"volume\":\"1 1\",\"pages\":\"29-34\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1089/jcr.2011.0001\",\"citationCount\":\"29\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of caffeine research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1089/jcr.2011.0001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of caffeine research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/jcr.2011.0001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 29
摘要
目的:本研究的目的是评估咖啡因摄入与体外受精(IVF)结果之间的关系。方法:共有2474对夫妇在接受第一个试管婴儿周期之前前瞻性入选，共4716个试管婴儿周期。采用离散生存分析调整观察到的混杂因素，量化咖啡因摄入与活产之间的关系。次要结果为卵母细胞回收、雌二醇峰值水平、着床率和受精率。结果:总体而言，女性摄入咖啡因与活产没有显著相关性(p趋势=0.74)。与不喝咖啡因的女性相比，低摄入量(>0-800毫克/周;优势比[OR]=1.00, 95%可信区间[CI])=0.83-1.21)，中度(>800-1400 mg/周;OR=0.89, 95% CI=0.71-1.12)或高水平咖啡因(>1400毫克/周;Or =1.07, 95% ci =0.85-1.34)。女性摄入更多的咖啡因与雌二醇峰值水平显著降低相关(p趋势=0.03)，但与获得的卵母细胞数量(p趋势=0.75)、受精率(p趋势=0.10)或着床率(p趋势=0.23)无关。男性摄入咖啡因与活产(ptrend=0.27)、受精(ptrend=0.72)或着床(ptrend=0.24)之间没有显著关联。女性或男性饮用咖啡、茶或苏打水对个体的影响与活产无关。结论:女性或男性摄入咖啡因与体外受精结果无关。
Effects of Caffeine Consumption by Women and Men on the Outcome of In Vitro Fertilization.
Objective: The objective of this study was to estimate the association between caffeine consumption and in vitro fertilization (IVF) outcomes.
Methods: A total of 2474 couples were prospectively enrolled prior to undergoing their first cycle of IVF, contributing a total of 4716 IVF cycles. Discrete survival analysis adjusting for observed confounders was applied to quantify the relation between caffeine consumption and livebirth. Secondary outcomes of interest were oocyte retrieval, peak estradiol level, implantation rate, and fertilization rate.
Results: Overall, caffeine consumption by women was not significantly associated with livebirth (ptrend=0.74). Compared with women who do not drink caffeine, the likelihood of livebirth was not significantly different for women who drank low (>0-800 mg/week; odds ratio [OR]=1.00, 95% confidence interval [CI])=0.83-1.21), moderate (>800-1400 mg/week; OR=0.89, 95% CI=0.71-1.12), or high levels of caffeine (>1400 mg/week; OR=1.07, 95% CI=0.85-1.34). Greater caffeine intake by women was associated with a significantly lower peak estradiol level (ptrend=0.03), but was not associated with the number of oocytes retrieved (ptrend=0.75), fertilization rate (ptrend=0.10), or implantation rate (ptrend=0.23). There was no significant association between caffeine intake by men and livebirth (ptrend=0.27), fertilization (ptrend=0.72), or implantation (ptrend=0.24). The individual effects of consumption of coffee, tea, or soda by women or men were not related to livebirth.
Conclusion: Caffeine consumption by women or men was not associated with IVF outcomes.
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