血清铁与冠状动脉疾病严重程度之间的关系

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Babak Bagheri, Mohammad Shokrzadeh, Vahid Mokhberi, Soheil Azizi, Alireza Khalilian, Negin Akbari, Valiallah Habibi, Keyvan Yousefnejad, Sasan Tabiban, Maryam Nabati
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引用次数: 0

摘要

背景:冠状动脉疾病(CAD)是全球最重要的死亡原因。大约一半的心血管风险因素尚未完全明了。铁等氧化剂对低密度脂蛋白的氧化在动脉粥样硬化中起着核心作用。因此,评估铁的储存量对于动脉粥样硬化疾病的风险评估非常重要:这项横断面研究的对象是 2010 年 2 月至 2012 年 7 月在马赞达兰医科大学萨里心脏中心住院的 337 名慢性稳定型心绞痛患者。两名心脏病专家对患者进行了冠状动脉造影术和血管造影评估。此外,在冠状动脉造影术前禁食 14 小时后采集血液样本,以测量总胆固醇、高密度脂蛋白胆固醇和葡萄糖。根据 Syntax 评分系统,患者被分为四组,以评估冠状动脉疾病(CAD)的严重程度:研究结果显示,四组患者的血清铁含量存在明显差异。严重动脉粥样硬化组的铁血清水平明显高于正常组(P=0.0122)、轻度组(P=0.023)和中度 CAD 组(PConclusions):研究结果表明,动脉粥样硬化患者血清中的铁含量较高,且随 CAD 的严重程度而增加。因此,血清铁水平与 CAD 之间可能存在基本关系。要证实铁含量与动脉粥样硬化之间的关系,还需要进一步的前瞻性研究和实验研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Serum Iron and the Severity of Coronary Artery Disease.

Background: Coronary Artery Disease (CAD) is the most important cause of mortality in the world. About half of cardiovascular risk factors have not been completely understood. Oxidation of LDL by oxidants such as iron plays a central role in atherogenesis. As a result, evaluation of the iron stores is important in the risk evaluation of the atherosclerotic disease.

Materials and methods: This cross sectional study was performed on 337 patients with chronic stable angina hospitalized in Sari heart center, Mazandaran University of Medical Sciences from February 2010 to July 2012. Coronary angiography was performed and the angiograms were evaluated by two cardiologists. Moreover, blood samples were collected after a 14-hour fast immediately before the coronary angiography in order to measure the total cholesterol, HDL- cholesterol, and glucose. The patients were divided into four groups to evaluate the severity of Coronary Artery Disease (CAD) according to Syntax scoring system.

Results: The study results revealed a significant difference among the four study groups regarding the iron serum level. It was significantly higher in the sever atherosclerosis group compared to the normal (P=0.0122), mild (P=0.023), and moderate CAD groups (P<0.001).

Conclusions: The findings indicated that the serum level of iron was higher in the atherosclerotic patients and increased with the severity of CAD. Therefore, a basic relationship probably exists between the serum iron level and CAD. Further prospective and experimental studies are needed to confirm the association between the iron status and atherosclerosis.

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来源期刊
International Cardiovascular Research Journal
International Cardiovascular Research Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
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0.40
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