前列腺增生和前列腺癌患者血清PSA水平和血管生成活性的影响

A. Ben Jemaa , Y. Bouraoui , S. Sallami , A. Banasr , Y. Nouira , R. Oueslati
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引用次数: 4

摘要

目的前列腺特异性抗原(PSA)-前列腺特异性膜抗原(PSMA)谱在病理性前列腺(增生和癌)中的相关性尚不完全清楚。本研究的目的是探讨PSA- psma谱对良性前列腺增生(BPH)和前列腺癌(PC)血清PSA水平和血管生成活性的影响。患者和方法本研究对6例正常前列腺(NP)、29例前列腺增生(BPH)和33例前列腺增生(PC)进行了研究,Gleason分级为>8. 已进行免疫组织化学分析。单克隆抗体3E6和ER-PR8分别用于评估PSMA和PSA的表达。利用CD34免疫标志物对血管生成进行评价。用Immulite自动分析仪测定血清PSA水平。结果各蛋白在不同血清PSA水平下的表达及血管生成活性均在不同PSA水平下的PC患者中最高;20 ng / mL。然而,在PC患者中,后一种血清PSA组的组织PSA表达最低。最相关的结果显示,在PC患者中(PSA+, PSMA+)和(PSA -, PSMA+)谱与血清PSA水平呈负相关。在PC患者中,血清PSA组检测到(PSA+, PSMA+)谱的高免疫表达>20 ng / mL;而血清PSA组在0 ~ 4 ng/mL之间检测到(PSA -, PSMA+)谱的高免疫表达。具有(PSA+, PSMA+)特征的PC患者血管生成活性最高。结论我们的研究结果清楚地支持了psma - psma谱改善前列腺癌患者体内诊断和治疗方法的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PSA-PSMA profiles and their impact on sera PSA levels and angiogenic activity in hyperplasia and human prostate cancer

Aim

The relevance of prostate specific antigen (PSA)-prostate specific membrane antigen (PSMA) profiles in pathologic prostate (hyperplasia and cancer) has not been fully understood. The aim of this study is to investigate the impact of PSA-PSMA profiles on sera PSA levels and angiogenic activity in benign prostate hyperplasia (BPH) and prostate carcinoma (PC).

Patients and methods

The study has been carried out in 6 normal prostate (NP), 29 BPH and 33 PC with dominant Gleason grade > 8. Immunohistochemical analysis has been performed. Monoclonal antibodies 3E6 and ER-PR8 have been used to assess PSMA and PSA expression respectively. The evaluation of angiogenesis has been made by CD34 immune marker. Serum levels of PSA have been assayed by Immulite autoanalyser.

Results

The study of each protein separately among sera PSA levels showed that PSMA expression and angiogenic activity have the highest intensity in PC patients with serum PSA levels > 20 ng/mL. Nevertheless, the lowest tissue PSA expression was found in PC patients with this latter sera PSA group. The most relevant results showed that in PC patients (PSA+, PSMA+) and (PSA–, PSMA+) profile were found to be inversely related to sera PSA levels. In PC patients, a high immunoexpression of (PSA+, PSMA+) profile has detected in the sera PSA group > 20 ng/mL; whereas a high immunoexpression of (PSA–, PSMA+) profile was detected in the sera PSA group between 0 and 4 ng/mL. The highest angiogenic activity was found in PC patients with (PSA+, PSMA+) profile.

Conclusions

Our findings clearly have supported the feasibility of PSA-PSMA profiles to improve in vivo diagnostic and therapeutic approaches in prostate cancer patients.

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来源期刊
Pathologie-biologie
Pathologie-biologie 医学-病理学
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