橡胶球囊在体测量麻醉大鼠胃内压

Current protocols in toxicology Pub Date : 2018-02-16 DOI:10.1002/0471140856.tx2112s57

Zoltán S. Zádori, Klára Gyires

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引用次数: 3

摘要

本单元描述的方案旨在通过充满水的低顺应性橡胶球囊测量麻醉大鼠的胃内压。气囊可以通过口腔(通过将气囊沿食道向下)或剖腹手术后直接通过眼底小切口进入胃。刺激性药物(如甲萘酚)和抑制性药物(如羟甲氧苄唑啉)对胃张力和期相收缩的影响均可评价。该模型允许评估剂量-反应曲线以及效应的时间过程。此外，通过联合中枢或外周作用剂，也可以确定作用部位。咕咕叫。Protoc。Toxicol 57:21.12.1-21.12.11。©2013 by John Wiley &儿子,Inc。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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In Vivo Measurement of Intragastric Pressure with a Rubber Balloon in the Anesthetized Rat

The protocols described in this unit are designed to measure the intragastric pressure in anesthetized rats by a water-filled low-compliance rubber balloon. The balloon is introduced into the stomach either orally (by passing the balloon down the esophagus) or directly via a small incision of the fundus after laparotomy. The effects of both stimulatory (e.g., carbachol) and inhibitory (e.g., oxymetazoline) agents can be evaluated on the gastric tone and phasic contractions. The model allows the evaluation of dose-response curves and also the time-course of the effects. Furthermore, by combining centrally or peripherally acting agents the site of action can also be determined. Curr. Protoc. Toxicol. 57:21.12.1-21.12.11. © 2013 by John Wiley & Sons, Inc.

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Current protocols in toxicology

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