{"title":"SIRT1/PARP1 相互交织：连接 DNA 损伤和新陈代谢。","authors":"Augustin Luna, Mirit I Aladjem, Kurt W Kohn","doi":"10.1186/2041-9414-4-6","DOIUrl":null,"url":null,"abstract":"<p><p>An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulators of DNA damage response and circadian rhythms. We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins. Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those interactions in DNA repair and ultimately, cell fate decisions. </p>","PeriodicalId":53596,"journal":{"name":"Genome Integrity","volume":"4 1","pages":"6"},"PeriodicalIF":0.0000,"publicationDate":"2013-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898398/pdf/","citationCount":"0","resultStr":"{\"title\":\"SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.\",\"authors\":\"Augustin Luna, Mirit I Aladjem, Kurt W Kohn\",\"doi\":\"10.1186/2041-9414-4-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulators of DNA damage response and circadian rhythms. We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins. Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those interactions in DNA repair and ultimately, cell fate decisions. </p>\",\"PeriodicalId\":53596,\"journal\":{\"name\":\"Genome Integrity\",\"volume\":\"4 1\",\"pages\":\"6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898398/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genome Integrity\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/2041-9414-4-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genome Integrity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/2041-9414-4-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
摘要
调节 SIRT1 和 PARP1 蛋白活性的网络错综复杂，并且仍在不断被发现。SIRT1 和 PARP1 都有一个共同的辅助因子烟酰胺腺嘌呤二核苷酸（NAD+）和几个共同的底物，包括 DNA 损伤反应和昼夜节律的调节因子。我们利用交互式分子相互作用图（MIM）回顾了这一复杂的网络，以探索这两种蛋白质之间的相互作用。在此，我们讨论了 NAD + 竞争和转录后/翻译反馈机制如何创建一个对环境线索（如基因毒性应激和代谢状态）敏感的调控网络，并研究了这些相互作用在 DNA 修复和最终细胞命运决定中的作用。
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.
An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulators of DNA damage response and circadian rhythms. We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins. Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those interactions in DNA repair and ultimately, cell fate decisions.
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