心脏型脂肪酸结合蛋白可在因胸痛入院时排除急性心肌梗死。

Acute cardiac care Pub Date : 2013-12-01 Epub Date: 2013-11-06 DOI:10.3109/17482941.2013.841947
Fabrizio Cappellini, Simona Da Molin, Stefano Signorini, Fausto Avanzini, Donata Saltafossi, Rosanna Falbo, Paolo Brambilla
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引用次数: 16

摘要

胸痛是急诊科(ED)就诊的最常见原因之一,尽管急诊中AMI(急性心肌梗死)的估计患病率约为4%。AMI的诊断标准之一是心肌肌钙蛋白的升高和/或下降,但这需要时间。因此,使用额外的心脏损伤“早期标记”可能有助于迅速排除AMI。该研究的目的是通过测定胸痛急诊科患者基线样本的心脏型脂肪酸结合蛋白(H-FABP)来评估排除AMI的可能性。26例AMI患者和41例非AMI对照纳入研究。在这些受试者的基线样本中测量H-FABP和高敏感性心肌肌钙蛋白T (hs-cTnT)。H-FABP的阴性预测值为100%,这表明在胸痛患者急诊AMI的排除策略中使用H-FABP的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Heart-type fatty acid-binding protein may exclude acute myocardial infarction on admission to emergency department for chest pain.

Chest pain is one of the most frequent reasons for presentation to the emergency department (ED), although the estimated prevalence of AMI (acute myocardial infarction) in the ED is about 4%. One criterion for diagnosis of AMI is the demonstration of a rise and/or fall in cardiac troponins, but time is needed for this to happen. Thus, the use of an additional 'early marker' of cardiac injury may aid to exclude AMI rapidly. The aim of the study was to evaluate the possibility of excluding AMI with the determination of heart-type fatty acid-binding protein (H-FABP) on baseline samples of patients referring to the ED for chest pain. 26 AMI patients and 41 non-AMI comparisons were included in the study. Both H-FABP and high sensitivity cardiac troponin T (hs-cTnT) were measured in baseline samples from these subjects. H-FABP had a negative predictive value of 100%, thus indicating the possibility of its usage in a rule-out strategy for AMI in ED for patients presenting with chest pain.

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