表皮生长因子受体在鼻咽癌预后中的作用:荟萃分析。

Head & Neck Pub Date : 2014-10-01 Epub Date: 2013-12-18 DOI:10.1002/hed.23481

Wei Sun, Guoxian Long, Junfeng Wang, Qi Mei, Dongbo Liu, Guoqing Hu

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引用次数: 29

摘要

背景:各种研究评估了表皮生长因子受体(EGFR)过表达在鼻咽癌(NPC)中的预后价值，但其结果仍存在争议。方法:收集截至2013年1月已发表的研究。共纳入16项研究，涉及1179例患者。进行了一项荟萃分析，以阐明EGFR在鼻咽癌患者中的预后作用。使用固定效应或随机效应模型估计联合风险比(HR)和95%置信区间(CI)。结果:EGFR过表达对总生存期(OS;人力资源,1.86;95% CI, 1.25-2.77)，无病生存期(DFS;人力资源,2.25;95% CI, 1.66-3.04)和局部区域对照(HR, 2.93;95% ci, 1.71-5.02)。然而，EGFR过表达与远端无转移生存之间的相关性无统计学意义(HR, 1.39;95% ci, 0.72-2.67)。结论:EGFR过表达可能是鼻咽癌患者预后的一个影响因素。

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Prognostic role of epidermal growth factor receptor in nasopharyngeal carcinoma: a meta-analysis.

Background: Various studies have assessed the prognostic value of epidermal growth factor receptor (EGFR) overexpression in nasopharyngeal carcinoma (NPC), but their results remain controversial.

Methods: Studies published up to January 2013 were collected. A total of 16 studies involving 1179 patients were reviewed. A meta-analysis was performed to clarify the prognostic role of EGFR in patients with NPC. The combined hazard ratio (HR) and 95% confidence interval (CI) were estimated using fixed-effects or random-effects models.

Results: EGFR overexpression had significantly poor effect on overall survival (OS; HR, 1.86; 95% CI, 1.25-2.77), disease-free survival (DFS; HR, 2.25; 95% CI, 1.66-3.04) and locoregional control (HR, 2.93; 95% CI, 1.71-5.02). However, the association between EGFR overexpression and distant metastasis-free survival was not statistically significant (HR, 1.39; 95% CI, 0.72-2.67).

Conclusion: EGFR overexpression can be a prognostic factor for patients with NPC.

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Head & Neck

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