抗磷脂综合征作为复发性心肌梗死的一个原因。

Acute cardiac care Pub Date : 2013-09-01 Epub Date: 2013-08-08 DOI:10.3109/17482941.2013.821203
David Snipelisky, Fernando Stancampiano, Brian Shapiro
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引用次数: 6

摘要

本病例描述了一个在两周内发生三次心肌梗死的病人。检测证实血栓形成是病因。病例:一名55岁男性,最初以胸痛主诉到急诊科就诊。检测显示肌钙蛋白升高2.2 ng/ml,心电图显示ST段升高。患者被转移到心导管实验室,放置药物洗脱支架。首次放置支架1天后,发现药物洗脱支架内血栓形成。行血管成形术和吸入性取栓术,3天后患者出院。出院后72小时,患者因反复胸痛和出汗返回急诊科。到达后不久,他变得无反应,遥测显示室性心动过速,并随心律转复消退。导管实验室再次发现右冠状动脉再闭塞,并放置了三个裸金属支架。实验室检测发现存在抗心磷脂抗体和PT20201A突变的证据。结论:高凝状态虽然是心肌梗死的罕见原因,但在研究复发性冠状动脉事件的病因时应予以考虑。及时治疗对于预防今后再次发生非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiphospholipid syndrome as a cause for recurrent myocardial infarction.

Introduction: This case describes a patient who suffered three myocardial infarctions over a two-week period. Testing confirmed thrombophilia as the etiology.

Case: A 55-year old male initially presented to the emergency department with a complaint of chest pain. Testing showed an elevated troponin at 2.2 ng/ml and ST elevations on electrocardiogram. The patient was transferred to the cardiac catheterization laboratory and a drug-eluting stent was placed. One day after the initial stent placement, in-stent thrombosis of the drug-eluting stent was discovered. Angioplasty and aspiration thrombectomy were performed, and the patient was released from the hospital three days later. 72 h after his discharge, the patient returned to the emergency department due to recurrent chest pain and diaphoresis. Shortly after arrival he became unresponsive and telemetry showed ventricular tachycardia which resolved with cardioversion. Reocclusion of the right coronary artery was again noted in the catheterization laboratory and three bare metal stents were placed. Laboratory testing found presence of anticardiolipin antibody and evidence of PT20201A mutation.

Conclusion: Hypercoagulable states, although an uncommon cause of myocardial infarction, should be considered when investigating the etiology of recurrent coronary events. Prompt treatment is important in the prevention of future occurrences.

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