{"title":"HBV基因型分布及其与临床表现关系的初步研究。","authors":"Jing Sun, Zhi-Yuan Jia, Jun-Xia Chang, Wei Liu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between HBV genotypes distribution in hepatitis B patients and clinical manifestations in Beijing area.</p><p><strong>Methods: </strong>200 HBsAg positive serum were choosen from 1148 serum samples. useing of nested PCR amplification method, HBV DNA S genes were Sequencing and typing; genotype distribution and the relationship with the clinical manifestation were Statistical analysis.</p><p><strong>Results: </strong>In Beijing area, HBV has B, C, D three genotypes, including B gene type 17 cases (12. 5%), C genotype 116 cases (85.2%), D genotype 3 cases (0.02%); in the carriers, patients with chronic hepatitis B, cirrhosis, liver cancer, B type have been gradually falling, C type have been gradually rising trend.</p><p><strong>Conclusion: </strong>Serious liver disease relate with C type, B type patients with HBV infection is better than C type patients in clinical prognosis and antivirus treatment response.</p>","PeriodicalId":70973,"journal":{"name":"中华实验和临床病毒学杂志","volume":"27 1","pages":"39-41"},"PeriodicalIF":0.0000,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The preliminary study of HBV genotype distribution and the relationship with clinical manifestation].\",\"authors\":\"Jing Sun, Zhi-Yuan Jia, Jun-Xia Chang, Wei Liu\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the relationship between HBV genotypes distribution in hepatitis B patients and clinical manifestations in Beijing area.</p><p><strong>Methods: </strong>200 HBsAg positive serum were choosen from 1148 serum samples. useing of nested PCR amplification method, HBV DNA S genes were Sequencing and typing; genotype distribution and the relationship with the clinical manifestation were Statistical analysis.</p><p><strong>Results: </strong>In Beijing area, HBV has B, C, D three genotypes, including B gene type 17 cases (12. 5%), C genotype 116 cases (85.2%), D genotype 3 cases (0.02%); in the carriers, patients with chronic hepatitis B, cirrhosis, liver cancer, B type have been gradually falling, C type have been gradually rising trend.</p><p><strong>Conclusion: </strong>Serious liver disease relate with C type, B type patients with HBV infection is better than C type patients in clinical prognosis and antivirus treatment response.</p>\",\"PeriodicalId\":70973,\"journal\":{\"name\":\"中华实验和临床病毒学杂志\",\"volume\":\"27 1\",\"pages\":\"39-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华实验和临床病毒学杂志\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华实验和临床病毒学杂志","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:探讨北京地区乙型肝炎患者HBV基因型分布与临床表现的关系。方法:从1148份血清中抽取200份HBsAg阳性血清。采用巢式PCR扩增法对HBV DNA S基因进行测序分型;对基因型分布及与临床表现的关系进行统计学分析。结果:北京地区HBV有B、C、D三种基因型，其中B基因型17例(12例)。C基因型116例(85.2%)，D基因型3例(0.02%);在携带者中，慢性乙型肝炎、肝硬化、肝癌患者中，B型有逐渐下降的趋势，C型有逐渐上升的趋势。结论:严重肝病与C型相关，B型患者合并HBV感染的临床预后及抗病毒治疗效果优于C型患者。
[The preliminary study of HBV genotype distribution and the relationship with clinical manifestation].
Objective: To explore the relationship between HBV genotypes distribution in hepatitis B patients and clinical manifestations in Beijing area.
Methods: 200 HBsAg positive serum were choosen from 1148 serum samples. useing of nested PCR amplification method, HBV DNA S genes were Sequencing and typing; genotype distribution and the relationship with the clinical manifestation were Statistical analysis.
Results: In Beijing area, HBV has B, C, D three genotypes, including B gene type 17 cases (12. 5%), C genotype 116 cases (85.2%), D genotype 3 cases (0.02%); in the carriers, patients with chronic hepatitis B, cirrhosis, liver cancer, B type have been gradually falling, C type have been gradually rising trend.
Conclusion: Serious liver disease relate with C type, B type patients with HBV infection is better than C type patients in clinical prognosis and antivirus treatment response.
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