HPV e2 -宿主蛋白-蛋白相互作用:细胞网络的复杂劫持。

The Open Virology Journal Pub Date : 2012-01-01 Epub Date: 2012-12-28 DOI:10.2174/1874357901206010173
Mandy Muller, Caroline Demeret
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引用次数: 0

摘要

人类乳头瘤病毒(hpv)的100多种基因型已被确定为导致隐性感染或从良性皮肤或生殖器疣到癌症等病变的原因。HPV的发病机制是由病毒和宿主因素之间的复杂关系引起的,特别是由宿主蛋白质组和早期病毒蛋白之间的相互作用驱动的。E2蛋白通过将宿主细胞因子募集到HPV调控区,调控病毒基因组的转录、复制以及有丝分裂分离。因此,它是多产的病毒生命周期和病毒持久性的关键因素,是癌症发展的主要危险因素。此外,E2蛋白已被证明参与许多相互作用,通过它们在调节宿主细胞中发挥重要作用。这种E2活性可能有助于为病毒生命周期的连续阶段创造适合的细胞条件,其中一些活性仅在致癌高风险的HPV中得到证实。最近绘制的e2 -宿主蛋白-蛋白质相互作用与HPV多样性的12个基因型的代表,揭示了宿主细胞劫持的复杂性及其根据病毒基因型的多样性。本文回顾了E2与宿主蛋白质组相互作用中E2的功能,并考虑了大规模的比较相互作用研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The HPV E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network.

The HPV E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network.

The HPV E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network.

The HPV E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network.

Over 100 genotypes of human papillomaviruses (HPVs) have been identified as being responsible for unapparent infections or for lesions ranging from benign skin or genital warts to cancer. The pathogenesis of HPV results from complex relationships between viral and host factors, driven in particular by the interplay between the host proteome and the early viral proteins. The E2 protein regulates the transcription, the replication as well as the mitotic segregation of the viral genome through the recruitment of host cell factors to the HPV regulatory region. It is thereby a pivotal factor for the productive viral life cycle and for viral persistence, a major risk factor for cancer development. In addition, the E2 proteins have been shown to engage numerous interactions through which they play important roles in modulating the host cell. Such E2 activities are probably contributing to create cell conditions appropriate for the successive stages of the viral life cycle, and some of these activities have been demonstrated only for the oncogenic high-risk HPV. The recent mapping of E2-host protein-protein interactions with 12 genotypes representative of HPV diversity has shed some light on the large complexity of the host cell hijacking and on its diversity according to viral genotypes. This article reviews the functions of E2 as they emerge from the E2/host proteome interplay, taking into account the large-scale comparative interactomic study.

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