肾移植后伴单克隆IgG沉积的复发性增生性肾小球肾炎1例。

Case reports in nephrology and urology Pub Date : 2012-01-01 Epub Date: 2012-06-05 DOI:10.1159/000339405
Andrea Ranghino, Michela Tamagnone, Maria Messina, Antonella Barreca, Luigi Biancone, Bruno Basolo, Giuseppe Paolo Segoloni, Gianna Mazzucco
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引用次数: 18

摘要

增殖性肾小球肾炎伴单克隆IgG沉积(PGNMID)是一种罕见的新近发现的疾病,无论治疗如何,预后都很差。最近,肾移植后复发或新发PGNMID的可能性有所报道,与原生肾脏的PGNMID相比,其预后更好。然而,目前,由于很少有复发性PGNMID的病例被诊断出来,没有被证明有效的治疗方法。在这里,我们报告一例复发性PGNMID成功治疗血浆置换,类固醇和霉酚酸酯。我们的报告提示血浆置换可能是治疗复发性PGNMID的有效治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits after kidney transplant treated with plasmapheresis.

A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits after kidney transplant treated with plasmapheresis.

A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits after kidney transplant treated with plasmapheresis.

Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a rare and recently identified disease with a poor prognosis irrespective of the treatment. Recently, the possibility of recurrent or de novo PGNMID after kidney transplantation has been reported, which is associated with a better prognosis compared to PGNMID on native kidneys. Nevertheless, at present, due to the very few cases of recurrent PGNMID diagnosed, there is no proven effective treatment. Here, we report a case of recurrent PGNMID successfully treated with plasmapheresis, steroids and mycophenolate mofetil. Our report suggests that plasmapheresis might be a valid therapeutic option to treat recurrent PGNMID.

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