导致酗酒的基因:综述。

IF 6.8 1区医学 Q1 SUBSTANCE ABUSE

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Howard J Edenberg

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引用次数: 0

摘要

遗传因素(即特定基因的变异)占酗酒风险的很大一部分。然而，识别这些基因和相关的特定变异是具有挑战性的。研究人员使用病例对照和家庭研究来确定与酒精中毒风险相关的基因。此外，不同的策略，如候选基因分析和全基因组关联研究已被使用。对酒精代谢中涉及的两种酶——酒精脱氢酶和醛脱氢酶的编码基因的特定变异产生了最强烈的影响。越来越多的证据表明，许多其他基因的变异具有较小但可测量的影响。

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Genes contributing to the development of alcoholism: an overview.

Genetic factors (i.e., variations in specific genes) account for a substantial portion of the risk for alcoholism. However, identifying those genes and the specific variations involved is challenging. Researchers have used both case-control and family studies to identify genes related to alcoholism risk. In addition, different strategies such as candidate gene analyses and genome-wide association studies have been used. The strongest effects have been found for specific variants of genes that encode two enzymes involved in alcohol metabolism-alcohol dehydrogenase and aldehyde dehydrogenase. Accumulating evidence indicates that variations in numerous other genes have smaller but measurable effects.

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来源期刊

Alcohol Research : Current Reviews SUBSTANCE ABUSE-

自引率

1.10%

发文量

期刊介绍： Alcohol Research: Current Reviews (ARCR) is an open-access, peer-reviewed journal published by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) at the National Institutes of Health. Starting from 2020, ARCR follows a continuous, rolling publication model, releasing one virtual issue per yearly volume. The journal offers free online access to its articles without subscription or pay-per-view fees. Readers can explore the content of the current volume, and past volumes are accessible in the journal's archive. ARCR's content, including previous titles, is indexed in PubMed, PsycINFO, Scopus, and Web of Science.