多肽作为抑制剂和移酶体的潜力:从噬菌体展示文库中选择模拟碳水化合物的多肽。

IF 1.3 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Nucleic Acids Pub Date : 2012-01-01 Epub Date: 2012-10-10 DOI:10.1155/2012/740982
Teruhiko Matsubara
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引用次数: 24

摘要

糖缀合物在生物过程中起着多种作用。特别是动物细胞表面的寡糖参与病毒感染和细胞间通讯。碳水化合物-蛋白质相互作用抑制剂是潜在的抗病毒药物。一些抗流感药物,如奥司他韦和扎那米韦,是唾液酸的衍生物,可以抑制神经氨酸酶。然而,通过化学合成或天然产物的分离制备多种糖衍生物是非常困难的。此外,细菌的致病性荚膜多糖是碳水化合物抗原,需要一种安全有效的疫苗接种方法。噬菌体展示技术已经得到改进,能够从大量肽序列中识别与碳水化合物结合蛋白(如凝集素和抗体)结合的肽。这些肽被称为“碳水化合物模拟肽(CMPs)”,因为它们模拟碳水化合物的结构。与碳水化合物衍生物相比,它易于制备单价和多价肽,然后对其进行修饰以生成各种衍生物。这种模拟肽可作为碳水化合物-蛋白质相互作用的肽抑制剂和与疫苗接种佐剂结合的肽模位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Potential of peptides as inhibitors and mimotopes: selection of carbohydrate-mimetic peptides from phage display libraries.

Potential of peptides as inhibitors and mimotopes: selection of carbohydrate-mimetic peptides from phage display libraries.

Potential of peptides as inhibitors and mimotopes: selection of carbohydrate-mimetic peptides from phage display libraries.

Potential of peptides as inhibitors and mimotopes: selection of carbohydrate-mimetic peptides from phage display libraries.

Glycoconjugates play various roles in biological processes. In particular, oligosaccharides on the surface of animal cells are involved in virus infection and cell-cell communication. Inhibitors of carbohydrate-protein interactions are potential antiviral drugs. Several anti-influenza drugs such as oseltamivir and zanamivir are derivatives of sialic acid, which inhibits neuraminidase. However, it is very difficult to prepare a diverse range of sugar derivatives by chemical synthesis or by the isolation of natural products. In addition, the pathogenic capsular polysaccharides of bacteria are carbohydrate antigens, for which a safe and efficacious method of vaccination is required. Phage-display technology has been improved to enable the identification of peptides that bind to carbohydrate-binding proteins, such as lectins and antibodies, from a large repertoire of peptide sequences. These peptides are known as "carbohydrate-mimetic peptides (CMPs)" because they mimic carbohydrate structures. Compared to carbohydrate derivatives, it is easy to prepare mono- and multivalent peptides and then to modify them to create various derivatives. Such mimetic peptides are available as peptide inhibitors of carbohydrate-protein interactions and peptide mimotopes that are conjugated with adjuvant for vaccination.

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来源期刊
Journal of Nucleic Acids
Journal of Nucleic Acids BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.10
自引率
21.70%
发文量
5
审稿时长
12 weeks
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