Min-Young Oh, Sang-Bo Oh, Hyeog-Gyu Seoung, Ji-Hye Kim, Sang-Mi Kim, Tae-Kyun Kim, Moo-Kon Song, Ho-Jin Shin, Joo-Seop Chung
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All patients had undergone an initial 18-FDG PET/CT and conventional computed tomography (CT) of the neck, chest, abdomen, and pelvis for staging. Median follow-up period was 35 months.</p><p><strong>Results: </strong>The SUVmax and MTD cut-off values were 11.0 and 7.5 cm, respectively. SUVmax≥11.0 predicted a short progression free survival (PFS, P=0.002) and overall survival (OS, P=0.002). MTD≥7.5 cm was associated with poor PFS (P=0.003) and OS (P=0.003). High International Prognostic Index (IPI) was also associated with the survival outcome (PFS, P=0.046; OS, P=0.030). Multivariate analysis revealed that SUVmax≥11.0 (PFS, hazard ratio [HR]=10.813, P=0.024; OS, HR=6.312, P=0.015); MTD≥7.5 cm (PFS, HR=5.631, P=0.008; OS, HR=4.072, P=0.008); and high IPI (PFS, P=0.027; OS, P=0.046) were independent prognostic factors.</p><p><strong>Conclusion: </strong>It appears that both MTD and SUVmax can be independent prognostic factors in primary extranodal DLBCL.</p>","PeriodicalId":23001,"journal":{"name":"The Korean Journal of Hematology","volume":"47 3","pages":"207-12"},"PeriodicalIF":0.0000,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5045/kjh.2012.47.3.207","citationCount":"11","resultStr":"{\"title\":\"Clinical significance of standardized uptake value and maximum tumor diameter in patients with primary extranodal diffuse large B cell lymphoma.\",\"authors\":\"Min-Young Oh, Sang-Bo Oh, Hyeog-Gyu Seoung, Ji-Hye Kim, Sang-Mi Kim, Tae-Kyun Kim, Moo-Kon Song, Ho-Jin Shin, Joo-Seop Chung\",\"doi\":\"10.5045/kjh.2012.47.3.207\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Maximum standardized uptake value (SUVmax) and maximum tumor diameter (MTD) have been shown to reflect survival outcome in diffuse large B cell lymphoma (DLBCL). However, applying these values to primary extranodal DLBCL is difficult because they are separate nosological entities with differences in genetic origin. We therefore decided to evaluate whether SUVmax and MTD on 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18-FDG) positron emission tomography (PET) would affect the survival outcome in primary extranodal DLBCL.</p><p><strong>Methods: </strong>From October 2005 to November 2010, 76 primary extranodal DLBCL patients receiving R-CHOP therapy were analyzed. All patients had undergone an initial 18-FDG PET/CT and conventional computed tomography (CT) of the neck, chest, abdomen, and pelvis for staging. Median follow-up period was 35 months.</p><p><strong>Results: </strong>The SUVmax and MTD cut-off values were 11.0 and 7.5 cm, respectively. SUVmax≥11.0 predicted a short progression free survival (PFS, P=0.002) and overall survival (OS, P=0.002). MTD≥7.5 cm was associated with poor PFS (P=0.003) and OS (P=0.003). High International Prognostic Index (IPI) was also associated with the survival outcome (PFS, P=0.046; OS, P=0.030). Multivariate analysis revealed that SUVmax≥11.0 (PFS, hazard ratio [HR]=10.813, P=0.024; OS, HR=6.312, P=0.015); MTD≥7.5 cm (PFS, HR=5.631, P=0.008; OS, HR=4.072, P=0.008); and high IPI (PFS, P=0.027; OS, P=0.046) were independent prognostic factors.</p><p><strong>Conclusion: </strong>It appears that both MTD and SUVmax can be independent prognostic factors in primary extranodal DLBCL.</p>\",\"PeriodicalId\":23001,\"journal\":{\"name\":\"The Korean Journal of Hematology\",\"volume\":\"47 3\",\"pages\":\"207-12\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.5045/kjh.2012.47.3.207\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Korean Journal of Hematology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5045/kjh.2012.47.3.207\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/9/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Korean Journal of Hematology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5045/kjh.2012.47.3.207","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/9/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
摘要
背景:最大标准化摄取值(SUVmax)和最大肿瘤直径(MTD)已被证明反映弥漫大B细胞淋巴瘤(DLBCL)的生存结局。然而，将这些值应用于原发性结外DLBCL是困难的，因为它们是独立的疾病实体，具有遗传起源的差异。因此，我们决定评估2-[氟-18]-氟-2-脱氧-d -葡萄糖(18-FDG)正电子发射断层扫描(PET)的SUVmax和MTD是否会影响原发性结外DLBCL的生存结果。方法:对2005年10月至2010年11月76例接受R-CHOP治疗的原发性结外大肝癌患者进行分析。所有患者都进行了最初的18-FDG PET/CT和常规的颈部、胸部、腹部和骨盆计算机断层扫描(CT)进行分期。中位随访期为35个月。结果:SUVmax和MTD临界值分别为11.0和7.5 cm。SUVmax≥11.0预测短期无进展生存期(PFS, P=0.002)和总生存期(OS, P=0.002)。MTD≥7.5 cm与不良PFS (P=0.003)和OS (P=0.003)相关。高国际预后指数(IPI)也与生存结果相关(PFS, P=0.046;操作系统,P = 0.030)。多因素分析显示SUVmax≥11.0 (PFS，风险比[HR]=10.813, P=0.024;Os, hr =6.312, p =0.015);MTD≥7.5 cm (PFS, HR=5.631, P=0.008;0, hr =4.072, p =0.008);高IPI (PFS, P=0.027);OS (P=0.046)是独立的预后因素。结论:MTD和SUVmax可能是原发性结外大细胞淋巴瘤的独立预后因素。
Clinical significance of standardized uptake value and maximum tumor diameter in patients with primary extranodal diffuse large B cell lymphoma.
Background: Maximum standardized uptake value (SUVmax) and maximum tumor diameter (MTD) have been shown to reflect survival outcome in diffuse large B cell lymphoma (DLBCL). However, applying these values to primary extranodal DLBCL is difficult because they are separate nosological entities with differences in genetic origin. We therefore decided to evaluate whether SUVmax and MTD on 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18-FDG) positron emission tomography (PET) would affect the survival outcome in primary extranodal DLBCL.
Methods: From October 2005 to November 2010, 76 primary extranodal DLBCL patients receiving R-CHOP therapy were analyzed. All patients had undergone an initial 18-FDG PET/CT and conventional computed tomography (CT) of the neck, chest, abdomen, and pelvis for staging. Median follow-up period was 35 months.
Results: The SUVmax and MTD cut-off values were 11.0 and 7.5 cm, respectively. SUVmax≥11.0 predicted a short progression free survival (PFS, P=0.002) and overall survival (OS, P=0.002). MTD≥7.5 cm was associated with poor PFS (P=0.003) and OS (P=0.003). High International Prognostic Index (IPI) was also associated with the survival outcome (PFS, P=0.046; OS, P=0.030). Multivariate analysis revealed that SUVmax≥11.0 (PFS, hazard ratio [HR]=10.813, P=0.024; OS, HR=6.312, P=0.015); MTD≥7.5 cm (PFS, HR=5.631, P=0.008; OS, HR=4.072, P=0.008); and high IPI (PFS, P=0.027; OS, P=0.046) were independent prognostic factors.
Conclusion: It appears that both MTD and SUVmax can be independent prognostic factors in primary extranodal DLBCL.
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