{"title":"通过锁开和锁闭通道解锁HCN通道门控机制。","authors":"Matthew C Trudeau","doi":"10.1085/jgp.201210898","DOIUrl":null,"url":null,"abstract":"Ion channels are highly specialized to respond to a wide range of environmental stimuli, including transmembrane voltage and chemical ligands ([Hille, 2001][1]). The response of channels to external cues causes a change in their ion conduction, which, in turn, modifies the behavior of excitable and","PeriodicalId":173753,"journal":{"name":"The Journal of General Physiology","volume":" ","pages":"457-61"},"PeriodicalIF":0.0000,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1085/jgp.201210898","citationCount":"4","resultStr":"{\"title\":\"Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels.\",\"authors\":\"Matthew C Trudeau\",\"doi\":\"10.1085/jgp.201210898\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ion channels are highly specialized to respond to a wide range of environmental stimuli, including transmembrane voltage and chemical ligands ([Hille, 2001][1]). The response of channels to external cues causes a change in their ion conduction, which, in turn, modifies the behavior of excitable and\",\"PeriodicalId\":173753,\"journal\":{\"name\":\"The Journal of General Physiology\",\"volume\":\" \",\"pages\":\"457-61\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1085/jgp.201210898\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of General Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1085/jgp.201210898\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/10/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of General Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1085/jgp.201210898","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/10/15 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels.
Ion channels are highly specialized to respond to a wide range of environmental stimuli, including transmembrane voltage and chemical ligands ([Hille, 2001][1]). The response of channels to external cues causes a change in their ion conduction, which, in turn, modifies the behavior of excitable and
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