六价铬暴露人群皮肤问题的遗传易感性。

IF 1.3 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Nucleic Acids Pub Date : 2012-01-01 Epub Date: 2012-07-26 DOI:10.1155/2012/968641
Priti Sharma, Vipin Bihari, Sudhir K Agarwal, Sudhir K Goel
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引用次数: 5

摘要

我们研究了遗传易感性对六价铬致皮肤逆境的影响。从地下水中六价铬含量升高的坎普尔(印度)地区对人口的健康状况进行了检查。采集血样进行DNA分离,进行基因多态性测定,分别为:NQO1 (C609T)、hOGG1 (C1245G)、GSTT1、GSTM1(缺失)。将有症状暴露者(n = 38)与无症状暴露者(n = 108)以及来自非污染参考社区的无症状对照者(n = 148)进行比较。暴露症状组有36.8%的受试者为GSTM1零基因型,而无症状组只有19.4%的受试者为零基因型。与野生基因型受试者相比,GSTM1零基因型暴露受试者更容易出现皮肤逆境(OR = 2.42;95% ci = 1.071-5.451)。没有发现年龄、吸烟、性别或居住时间对这种关联有任何混淆影响。与其他基因的关联在统计上不显着,尽管如此,不能排除这些基因的可能贡献。综上所述,GSTM1基因多态性状态的变化可能影响Cr(VI)污染地区居民的皮肤结局。因此,需要进一步的研究来检验不同人群的这些观察结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Genetic predisposition for dermal problems in hexavalent chromium exposed population.

Genetic predisposition for dermal problems in hexavalent chromium exposed population.

Genetic predisposition for dermal problems in hexavalent chromium exposed population.

We studied the effect of genetic susceptibility on hexavalent chromium induced dermal adversities. The health status of population was examined from the areas of Kanpur (India) having the elevated hexavalent chromium levels in groundwater. Blood samples were collected for DNA isolation to conduct polymorphic determination of genes, namely: NQO1 (C609T), hOGG1 (C1245G), GSTT1, and GSTM1 (deletion). Symptomatic exposed subjects (n = 38) were compared with asymptomatic exposed subjects (n = 108) along with asymptomatic controls (n = 148) from a non contaminated reference community. Exposed symptomatic group consisted of 36.8% subjects who were GSTM1 null genotyped as compared to asymptomatic where only 19.4% subjects were null. The exposed subjects with GSTM1 null genotype were more susceptible to dermal adversities in comparison with wild genotyped subjects (OR = 2.42; 95% CI = 1.071-5.451). Age, smoking, gender or duration of residence were not found to have any confounding effect towards this association. Association with other genes was not statistically significant, nonetheless, possible contribution by these genes cannot be ruled out. In conclusion, variation in the polymorphic status of GSTM1 gene may influence dermal outcomes among residents from Cr(VI) contaminated areas. Further studies are therefore, needed to examine these observations among different population groups.

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来源期刊
Journal of Nucleic Acids
Journal of Nucleic Acids BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.10
自引率
21.70%
发文量
5
审稿时长
12 weeks
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