DMN操作同步与自我意识有关:来自植物人和最低意识状态患者的证据。

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2012-01-01 Epub Date: 2012-07-27 DOI:10.2174/1874440001206010055
Andrew A Fingelkurts, Alexander A Fingelkurts, Sergio Bagnato, Cristina Boccagni, Giuseppe Galardi
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引用次数: 68

摘要

默认模式网络(DMN)在各种各样的自我相关任务中一直被激活,导致DMN在自我相关处理中的作用的提议。事实上,有有限的fMRI证据表明,DMN内的功能连接可能是一种被称为自我意识的现象的基础。同时,没有一项已知的研究明确地调查了构成DMN的大脑区域之间的神经元功能相互作用作为自我意识丧失的功能。为了填补这一空白,我们对植物人状态和最低意识状态的重型脑损伤患者进行脑电图操作同步分析[1,2],研究DMN操作同步强度作为自我意识表达的函数。我们发现植物人的DMN - EEG操作同步强度最小甚至不存在,在最低意识状态下处于中等水平,在健康的完全自我意识状态下处于最高水平。同时,由构成DMN的神经元集合执行的操作耦合过程在植物人状态下最高,在最低意识状态下中等,在健康的完全自我意识受试者中最低。与DMN的后脑模块相比,DMN的额叶脑电图操作模块的操作同步强度作为自我意识丧失的函数的下降幅度最大。上述结果表明,DMN功能连接的强度可能介导自我意识表达的强度。观察到的变化类似地发生在脑电图α, β 1和β 2频率振荡中。目前的结果表明,脑电图操作同步在DMN可能提供客观和准确的措施,以评估自我(非)意识的迹象,在这些具有挑战性的患者群体。因此,这种方法可以补充当前严重脑损伤患者的诊断程序,从而制定合理的康复干预计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

DMN Operational Synchrony Relates to Self-Consciousness: Evidence from Patients in Vegetative and Minimally Conscious States.

DMN Operational Synchrony Relates to Self-Consciousness: Evidence from Patients in Vegetative and Minimally Conscious States.

DMN Operational Synchrony Relates to Self-Consciousness: Evidence from Patients in Vegetative and Minimally Conscious States.

DMN Operational Synchrony Relates to Self-Consciousness: Evidence from Patients in Vegetative and Minimally Conscious States.

The default mode network (DMN) has been consistently activated across a wide variety of self-related tasks, leading to a proposal of the DMN's role in self-related processing. Indeed, there is limited fMRI evidence that the functional connectivity within the DMN may underlie a phenomenon referred to as self-awareness. At the same time, none of the known studies have explicitly investigated neuronal functional interactions among brain areas that comprise the DMN as a function of self-consciousness loss. To fill this gap, EEG operational synchrony analysis [1, 2] was performed in patients with severe brain injuries in vegetative and minimally conscious states to study the strength of DMN operational synchrony as a function of self-consciousness expression. We demonstrated that the strength of DMN EEG operational synchrony was smallest or even absent in patients in vegetative state, intermediate in patients in minimally conscious state and highest in healthy fully self-conscious subjects. At the same time the process of ecoupling of operations performed by neuronal assemblies that comprise the DMN was highest in patients in vegetative state, intermediate in patients in minimally conscious state and minimal in healthy fully self-conscious subjects. The DMN's frontal EEG operational module had the strongest decrease in operational synchrony strength as a function of selfconsciousness loss, when compared with the DMN's posterior modules. Based on these results it is suggested that the strength of DMN functional connectivity could mediate the strength of self-consciousness expression. The observed alterations similarly occurred across EEG alpha, beta1 and beta2 frequency oscillations. Presented results suggest that the EEG operational synchrony within DMN may provide an objective and accurate measure for the assessment of signs of self-(un)consciousness in these challenging patient populations. This method therefore, may complement the current diagnostic procedures for patients with severe brain injuries and, hence, the planning of a rational rehabilitation intervention.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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