TGF-β受体在纤维化中的作用。

Q4 Medicine

Open Rheumatology Journal Pub Date : 2012-01-01 Epub Date: 2012-06-15 DOI:10.2174/1874312901206010156

Sashidhar Nakerakanti, Maria Trojanowska

{"title":"TGF-β受体在纤维化中的作用。","authors":"Sashidhar Nakerakanti, Maria Trojanowska","doi":"10.2174/1874312901206010156","DOIUrl":null,"url":null,"abstract":"Recent advances in defining TGF-β signaling pathways have provided a new level of understanding of the role of this pleiotropic growth factor in the development of fibrosis. Here, we review selected topics related to the profibrotic role of TGF-β . We will discuss new insights into the mechanisms of ligand activation and the contribution of Erk1/2 MAPK, PI3K/FAK, and Endoglin/Smad1 signaling pathways to the process of fibrosis. There is growing evidence of the disease-specific alterations of the downstream components of the TGF-β signaling pathway that may be explored for the future therapeutic interventions.","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"6 ","pages":"156-62"},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1d/4f/TORJ-6-156.PMC3396054.pdf","citationCount":"70","resultStr":"{\"title\":\"The Role of TGF-β Receptors in Fibrosis.\",\"authors\":\"Sashidhar Nakerakanti, Maria Trojanowska\",\"doi\":\"10.2174/1874312901206010156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Recent advances in defining TGF-β signaling pathways have provided a new level of understanding of the role of this pleiotropic growth factor in the development of fibrosis. Here, we review selected topics related to the profibrotic role of TGF-β . We will discuss new insights into the mechanisms of ligand activation and the contribution of Erk1/2 MAPK, PI3K/FAK, and Endoglin/Smad1 signaling pathways to the process of fibrosis. There is growing evidence of the disease-specific alterations of the downstream components of the TGF-β signaling pathway that may be explored for the future therapeutic interventions.\",\"PeriodicalId\":39124,\"journal\":{\"name\":\"Open Rheumatology Journal\",\"volume\":\"6 \",\"pages\":\"156-62\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1d/4f/TORJ-6-156.PMC3396054.pdf\",\"citationCount\":\"70\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Rheumatology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874312901206010156\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/6/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Rheumatology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874312901206010156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/6/15 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 70

摘要

最近在定义TGF-β信号通路方面的进展为了解这种多效生长因子在纤维化发展中的作用提供了一个新的水平。在这里，我们回顾了与TGF-β促纤维化作用相关的主题。我们将讨论配体激活机制的新见解，以及Erk1/2 MAPK, PI3K/FAK和Endoglin/Smad1信号通路对纤维化过程的贡献。越来越多的证据表明，TGF-β信号通路下游组分的疾病特异性改变可能会为未来的治疗干预措施所探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Role of TGF-β Receptors in Fibrosis.

查看原文本刊更多论文

The Role of TGF-β Receptors in Fibrosis.

Recent advances in defining TGF-β signaling pathways have provided a new level of understanding of the role of this pleiotropic growth factor in the development of fibrosis. Here, we review selected topics related to the profibrotic role of TGF-β . We will discuss new insights into the mechanisms of ligand activation and the contribution of Erk1/2 MAPK, PI3K/FAK, and Endoglin/Smad1 signaling pathways to the process of fibrosis. There is growing evidence of the disease-specific alterations of the downstream components of the TGF-β signaling pathway that may be explored for the future therapeutic interventions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Open Rheumatology Journal Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： ENTHAM Open publishes a number of peer-reviewed, open access journals. These free-to-view online journals cover all major disciplines of science, medicine, technology and social sciences. BENTHAM Open provides researchers a platform to rapidly publish their research in a good-quality peer-reviewed journal. All peer-reviewed accepted submissions meeting high research and ethical standards are published with free access to all.