前庭分裂瘤的分子生物学及其与听力损失的关系：综述。

Q3 Biochemistry, Genetics and Molecular Biology

Genetics Research International Pub Date : 2012-01-01 Epub Date: 2012-02-20 DOI:10.1155/2012/856157

Erika Celis-Aguilar, Luis Lassaletta, Miguel Torres-Martín, F Yuri Rodrigues, Manuel Nistal, Javier S Castresana, Javier Gavilan, Juan A Rey

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引用次数: 0

摘要

听力损失是前庭分裂瘤（VS）患者最常见的症状。过去，肿瘤肿块及其生长造成的压迫机制被认为是导致前庭裂隙瘤听力损失的最可能原因。有趣的是，新的证据提出了分子机制来解释这种听力损失。提出的分子机制包括 TP73 的甲基化、细胞周期蛋白 D1 的负表达、B7-H1 的表达、血小板衍生生长因子 A 的表达增加、PEX5L、RAD54B 和 PSMAL 的表达不足以及 CEA 的过度表达。许多分子机制参与了前庭裂孔瘤的发展；我们将回顾其中的一些机制，并特别强调与前庭裂孔瘤相关的听力损失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The molecular biology of vestibular schwannomas and its association with hearing loss: a review.

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The molecular biology of vestibular schwannomas and its association with hearing loss: a review.

Hearing loss is the most common symptom in patients with vestibular schwannoma (VS). In the past, compressive mechanisms caused by the tumoral mass and its growth have been regarded as the most likely causes of the hearing loss associated with VS. Interestingly, new evidence proposes molecular mechanisms as an explanation for such hearing loss. Among the molecular mechanisms proposed are methylation of TP73, negative expression of cyclin D1, expression of B7-H1, increased expression of the platelet-derived growth factor A, underexpression of PEX5L, RAD54B, and PSMAL, and overexpression of CEA. Many molecular mechanisms are involved in vestibular schwannoma development; we review some of these mechanisms with special emphasis on hearing loss associated with vestibular schwannoma.

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来源期刊

Genetics Research International Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Genetics Research International is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of genetics and genomics. The journal focuses on articles bearing on heredity, biochemistry, and molecular biology, as well as clinical findings.