含环糊精聚合物:药物传递材料的多功能平台。

Journal of drug delivery Pub Date : 2012-01-01 Epub Date: 2012-02-02 DOI:10.1155/2012/262731
Jeremy D Heidel, Thomas Schluep
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引用次数: 59

摘要

纳米粒子作为一种潜在的治疗药物被广泛地应用于医学领域,并已被证明可以显著改善多种药物的循环、生物分布、疗效和安全性。一种主要的纳米颗粒涉及使用线性的、含环糊精的聚合物(cdp)。正如本文所讨论的那样,CDPs可以通过前药/药物分子与聚合物(Cyclosert平台的基础)的共价附着或阳离子CDPs与阴离子核酸有效载荷(RONDEL平台的基础)的非共价包合将治疗有效载荷结合到纳米颗粒中。对于这两种方法中的每一种,我们回顾了相关的分子结构及其原理,讨论了这些纳米颗粒的物理化学和生物学特性,并详细介绍了每种已获得临床评估的主要候选药物的进展。最后,我们展望了基于该技术的潜在未来研究方向和候选产品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cyclodextrin-containing polymers: versatile platforms of drug delivery materials.

Cyclodextrin-containing polymers: versatile platforms of drug delivery materials.

Cyclodextrin-containing polymers: versatile platforms of drug delivery materials.

Cyclodextrin-containing polymers: versatile platforms of drug delivery materials.

Nanoparticles are being widely explored as potential therapeutics for numerous applications in medicine and have been shown to significantly improve the circulation, biodistribution, efficacy, and safety profiles of multiple classes of drugs. One leading class of nanoparticles involves the use of linear, cyclodextrin-containing polymers (CDPs). As is discussed in this paper, CDPs can incorporate therapeutic payloads into nanoparticles via covalent attachment of prodrug/drug molecules to the polymer (the basis of the Cyclosert platform) or by noncovalent inclusion of cationic CDPs to anionic, nucleic acid payloads (the basis of the RONDEL platform). For each of these two approaches, we review the relevant molecular architecture and its rationale, discuss the physicochemical and biological properties of these nanoparticles, and detail the progress of leading drug candidates for each that have achieved clinical evaluation. Finally, we look ahead to potential future directions of investigation and product candidates based upon this technology.

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来源期刊
Journal of drug delivery
Journal of drug delivery PHARMACOLOGY & PHARMACY-
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