高负载荧光壳聚糖纳米颗粒的制备与表征。

ISRN Pharmaceutics Pub Date : 2011-01-01 Epub Date: 2011-11-17 DOI:10.5402/2011/246162
Haliza Katas, Chan Mui Wen
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引用次数: 12

摘要

壳聚糖(CS)纳米颗粒是一种多功能的药物传递系统,可将药物、基因、蛋白质和肽输送到靶点。近年来,由于在医学和干细胞研究中的各种应用,对荧光纳米粒子的需求增加了。本研究采用一种温和的方法,即复合凝聚法制备了荧光CS纳米颗粒。研究了CS纳米粒子负载磺胺(SR101)的包封效率,以评价其与荧光分子的包封能力。制备的荧光纳米颗粒的粒径在600 ~ 700 nm之间,其粒径高度依赖于CS的分子量和浓度。当SR101溶解于甲醇中时,其在CS纳米颗粒中的包封效率也很高。综上所述,采用复合凝聚法制备高负载的荧光CS纳米颗粒,可应用于各种医学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation and characterisation of highly loaded fluorescent chitosan nanoparticles.

Chitosan (CS) nanoparticles have been developed as a versatile drug delivery system to transport drugs, genes, proteins, and peptides into target sites. Demands on fluorescent nanoparticles have increased recently due to various applications in medical and stem-cell-based researches. In this study, fluorescent CS nanoparticles were prepared by a mild method, namely, complex coacervation. Entrapment efficiency of sulforhodamine (SR101) loaded into CS nanoparticles was investigated to evaluate their capacity in incorporating fluorescent molecule. Particle size of produced fluorescent nanoparticles was in the range of 600-700 nm, and their particle size was highly dependent on the CS molecular weight as well as concentration. A high entrapment efficiency of SR101 into CS nanoparticles could also be obtained when it was dissolved in methanol. In conclusion, highly loaded fluorescent CS nanoparticles could be easily prepared using complex coacervation method and therefore can be applied in various medical researches.

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