n -甲基- d -天冬氨酸受体2B特异性小干扰RNA通过激活MAP激酶对多巴胺神经元提供神经保护。

Q1 Medicine

Neurosignals Pub Date : 2013-01-01 Epub Date: 2012-02-23 DOI:10.1159/000334720

Olivia T W Ng, L W Chen, Y S Chan, Ken K L Yung

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引用次数: 5

摘要

在本研究中，n -甲基- d -天冬氨酸受体2B (NR2B)特异性siRNA应用于帕金森模型。我们之前的研究结果表明，n -甲基- d -天冬氨酸受体的关键亚基n -甲基- d -天冬氨酸受体1 (NR1)通过反义寡核苷酸的表达减少，可以改善帕金森病(PD)动物模型6-羟基多巴胺(6-OHDA)损伤大鼠的运动症状。

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Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase.

In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos ameliorated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

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来源期刊

Neurosignals 医学-神经科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neurosignals is an international journal dedicated to publishing original articles and reviews in the field of neuronal communication. Novel findings related to signaling molecules, channels and transporters, pathways and networks that are associated with development and function of the nervous system are welcome. The scope of the journal includes genetics, molecular biology, bioinformatics, (patho)physiology, (patho)biochemistry, pharmacology & toxicology, imaging and clinical neurology & psychiatry. Reported observations should significantly advance our understanding of neuronal signaling in health & disease and be presented in a format applicable to an interdisciplinary readership.