Sreeja Purushothaman, V K Ajitkumar, R Renuka Nair
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引用次数: 11
摘要
过氧化物酶体增殖物激活受体α (PPARα)的等位基因变异可通过影响脂质代谢而影响冠状动脉疾病(CAD)的风险。然而，PPARα内含子多态性在CAD中的作用很少受到关注。ppar - α基因内含子7的等位变异G/C与CAD的关系在医院的印度人群中进行了检查。对110例CAD男性患者和120例年龄和种族匹配的健康男性进行了PPAR基因分型，方法是PCR扩增该基因，然后限制性消化。C等位基因的存在与CAD呈正相关(OR = 2.9;95% ci [1.65-4.145];P = 0.009)，同时伴有血脂异常(OR = 2.95, 95% CI (1.5-4.39);P < 0.05)。PPARα内含子7C等位基因携带者的脂质代谢受损可能是CAD易感性的原因。
Association of PPARα Intron 7 Polymorphism with Coronary Artery Disease: A Cross-Sectional Study.
The allelic variants of peroxisome proliferator-activated receptor alpha (PPARα) can influence the risk of coronary artery disease (CAD) by virtue of its effect on lipid metabolism. However, the role of PPARα intronic polymorphism with CAD has received little attention. The association of allelic variants G/C at intron 7 of the PPAR-alpha gene with CAD was examined in a hospital-based Indian population. PPAR genotyping was performed in 110 male patients with CAD and 120 age and ethnically matched healthy males by PCR amplification of the gene followed by restriction digestion. Presence of C allele showed a positive association with CAD (OR = 2.9; 95% CI [1.65-4.145]; P = .009) and also with dyslipidaemia (OR = 2.95, 95% CI (1.5-4.39); P < .05). Impaired lipid metabolism in carriers of the PPARα Intron 7C allele is possibly responsible for the predilection to CAD.
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