单纯疱疹病毒生命周期的早期事件与终生感染的含义。

The Open Virology Journal Pub Date : 2012-01-01 Epub Date: 2012-01-19 DOI:10.2174/1874357901206010001
Sarah Salameh, Urmi Sheth, Deepak Shukla
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引用次数: 39

摘要

单纯疱疹病毒(HSV) 1型和2型主要引起口腔、眼部和生殖器疾病,影响很大比例的人群。感染开始于病毒进入宿主细胞,在此之前病毒可能沿着丝状足“冲浪”。然后,病毒糖蛋白结合一种或多种细胞表面受体,如疱疹病毒进入介质(HVEM)、连接素- 1,3 - o硫酸肝素(3-OS HS)、配对免疫球蛋白样受体α和非肌球蛋白iia。至少有五种病毒包膜糖蛋白参与进入,包括gB、gC、gD和gH-gL。进入后,这些糖蛋白也可能促进病毒的细胞间传播,这有助于逃避物理屏障以及先天和适应性免疫反应的几个组成部分。传播可能通过膜融合、在紧密连接上的移动、在神经元突触上的转移或含有肌动蛋白的结构的募集来促进。这篇综述总结了我们对HSV进入和细胞间传播的理解的一些最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Early events in herpes simplex virus lifecycle with implications for an infection of lifetime.

Early events in herpes simplex virus lifecycle with implications for an infection of lifetime.

Affecting a large percentage of human population herpes simplex virus (HSV) types -1 and -2 mainly cause oral, ocular, and genital diseases. Infection begins with viral entry into a host cell, which may be preceded by viral "surfing" along filopodia. Viral glycoproteins then bind to one or more of several cell surface receptors, such as herpesvirus entry mediator (HVEM), nectin-1, 3-O sulfated heparan sulfate (3-OS HS), paired immunoglobulin-like receptor α, and non-muscle myosin-IIA. At least five viral envelope glycoproteins participate in entry and these include gB, gC, gD and gH-gL. Post-entry, these glycoproteins may also facilitate cell-to-cell spread of the virus, which helps in the evasion of physical barriers as well as several components of the innate and adaptive immune responses. The spread may be facilitated by membrane fusion, movement across tight junctions, transfer across neuronal synapses, or the recruitment of actin-containing structures. This review summarizes some of the recent advances in our understanding of HSV entry and cell-to-cell spread.

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