M G Gündüz, C Safak, B Kaygısız, B C Koşar, R Simşek, K Erol, A Linden
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Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators.
In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.
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