脑血容量测量- Gd_DTPA vs. VASO -及其与激活的人视觉皮层脑血流量的关系。

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-11-04 DOI:10.2174/1874440001105010090
Ai-Ling Lin, Hanzhang Lu, Peter T Fox, Timothy Q Duong
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引用次数: 9

摘要

使用血管空间占用(VASO)技术(非侵入性和新开发的)和基于造影剂的(Gd- DTPA)方法(侵入性但已建立)与功能磁共振成像(fMRI)证明了任务引起的脑血容量(CBV)变化的测量。我们比较了两种方法在多频视觉刺激(4和8 Hz)时测定CBV的变化。具体而言,我们旨在评估重复时间(TR)对使用VASO测定CBV变化的影响。通过测定脑血流量(CBF),进一步测定脑流量-容量耦合关系(α值)和脑氧代谢率。结果表明:1)与GD-DTPA方法相比,使用VASO时,较短的TR (2s)会导致CBV变化的高估,而较长的TR (6s)会产生一致的CBV结果;ii) CBV变化的高估导致CMRO(2)变化被低估,但没有改变频率相关模式,即无论TR如何,4hz的CMRO(2)变化大于8hz;任务诱发的CBF-CBV耦合与刺激频率相关,即在4 Hz时α = 0.35-0.38,在8 Hz时α = 0.51-0.53。我们的数据表明,通过精心选择的TRs,可以使用VASO技术实现无创的CBV测量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cerebral Blood Volume Measurements - Gd_DTPA vs. VASO - and Their Relationship with Cerebral Blood Flow in Activated Human Visual Cortex.

Cerebral Blood Volume Measurements - Gd_DTPA vs. VASO - and Their Relationship with Cerebral Blood Flow in Activated Human Visual Cortex.

Cerebral Blood Volume Measurements - Gd_DTPA vs. VASO - and Their Relationship with Cerebral Blood Flow in Activated Human Visual Cortex.

Cerebral Blood Volume Measurements - Gd_DTPA vs. VASO - and Their Relationship with Cerebral Blood Flow in Activated Human Visual Cortex.

Measurements of task-induced changes in cerebral blood volume (CBV) have been demonstrated using VAscular Space Occupancy (VASO) techniques (noninvasive and newly developed) and a contrast agent-based (Gd- DTPA) method (invasive but well-established) with functional magnetic resonance imaging (fMRI). We compared the two methods in determining CBV changes during multi-frequency visual stimulation (4 and 8 Hz). Specifically, we aimed to assess the impact of repetition time (TR) on CBV changes determination using VASO. With additional measurements of cerebral blood flow (CBF), the flow-volume coupling relationship (α value) and cerebral metabolic rate of oxygen were further determined. The results showed that i) using VASO, short TR (2s) caused overestimation of CBV changes, while long TR (6s) generated consistent CBV results, by comparison to the GD-DTPA method; ii) overestimation of CBV changes caused underestimated CMRO(2) changes, but did not alter the frequency-related pattern, i.e., CMRO(2) changes at 4 Hz were greater than those at 8 Hz regardless of the TR; and iii) the tasked-induced CBF-CBV coupling was stimulus frequency-dependent, i.e., α = 0.35-0.38 at 4 Hz and α = 0.51-0.53 at 8 Hz. Our data demonstrated that, with carefully chosen TRs, CBV measurements can be achieved non-invasively with VASO techniques.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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