剪接程序和癌症。

IF 1.3 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Nucleic Acids Pub Date : 2012-01-01 Epub Date: 2011-10-24 DOI:10.1155/2012/269570
Sophie Germann, Lise Gratadou, Martin Dutertre, Didier Auboeuf
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引用次数: 46

摘要

许多研究报告了通过基因对基因的分析在多种癌症中的剪接改变。然而,对选择性剪接在癌症中的作用的理解现在达到了一个新的水平,这要归功于允许在大规模水平上分析剪接的新技术的使用。选择性剪接的全基因组分析表明,剪接改变可以影响参与关键细胞程序的基因网络产物。此外,许多在癌症中被鉴定为失调的剪接变异体在正常组织中表达。这些观察结果表明,剪接程序有助于在癌症发生和发展过程中改变特定的细胞程序。支持这一模型,最近的研究已经确定了剪接因子控制癌症相关剪接程序。剪接程序的特征和剪接因子对剪接程序的调控将有助于更好地理解癌症发生和发展的遗传机制,以及开发新的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Splicing programs and cancer.

Splicing programs and cancer.

Splicing programs and cancer.

Splicing programs and cancer.

Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis. However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies allowing the analysis of splicing at a large-scale level. Genome-wide analyses of alternative splicing indicate that splicing alterations can affect the products of gene networks involved in key cellular programs. In addition, many splicing variants identified as being misregulated in cancer are expressed in normal tissues. These observations suggest that splicing programs contribute to specific cellular programs that are altered during cancer initiation and progression. Supporting this model, recent studies have identified splicing factors controlling cancer-associated splicing programs. The characterization of splicing programs and their regulation by splicing factors will allow a better understanding of the genetic mechanisms involved in cancer initiation and progression and the development of new therapeutic targets.

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来源期刊
Journal of Nucleic Acids
Journal of Nucleic Acids BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.10
自引率
21.70%
发文量
5
审稿时长
12 weeks
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