叶酸补充与妊娠:预防神经管缺损不止如此。

Reviews in obstetrics & gynecology Pub Date : 2011-01-01
James A Greenberg, Stacey J Bell, Yong Guan, Yan-Hong Yu
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引用次数: 0

摘要

叶酸(维生素B(9))是DNA复制所必需的一种必需营养素,也是氨基酸合成和维生素代谢中一系列酶促反应的底物。怀孕期间对叶酸的需求增加,因为它也是胎儿生长发育所必需的。叶酸缺乏与母亲(贫血、周围神经病变)和胎儿(先天性异常)的异常有关。本文综述了叶酸的代谢、孕期补充叶酸的适当使用、叶酸的潜在益处,以及补充l-甲基叶酸预防神经管缺陷以外的妊娠相关并发症的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Folic Acid supplementation and pregnancy: more than just neural tube defect prevention.

Folate (vitamin B(9)) is an essential nutrient that is required for DNA replication and as a substrate for a range of enzymatic reactions involved in amino acid synthesis and vitamin metabolism. Demands for folate increase during pregnancy because it is also required for growth and development of the fetus. Folate deficiency has been associated with abnormalities in both mothers (anemia, peripheral neuropathy) and fetuses (congenital abnormalities). This article reviews the metabolism of folic acid, the appropriate use of folic acid supplementation in pregnancy, and the potential benefits of folic acid, as well as the possible supplementation of l-methylfolate for the prevention of pregnancy-related complications other than neural tube defects.

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