牙周炎患者β(1)-肾上腺素能受体自身抗体是心功能障碍的危险因素

ISRN dentistry Pub Date : 2011-01-01 Epub Date: 2011-09-07 DOI:10.5402/2011/791393
Marcela Segovia, Silvia Reina, Enri Borda, Leonor Sterin-Borda
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引用次数: 9

摘要

牙周炎(P)患者血清中存在针对β(1)-肾上腺素能受体(β(1)-AR)的自身抗体,使用心膜或与人β(1)-AR第二细胞外环对应的合成β(1)-AR肽作为抗原,使我们能够检测40例P患者的循环抗体,但在20例正常人(对照组)中没有。同时,P组患者HRV下降。抗β(1)-AR IgG滴度与患者HRV的降低相关,抗β(1)-AR肽IgG表现出部分激动剂样活性,可以改变离体心房的收缩性,产生环核苷酸,抑制异丙肾上腺素的β(1)-AR激动活性。我们在这项研究中证明了牙周炎感染与心脏病风险增加之间的关联,从而强调了抗β(1)-AR自身抗体在心肌收缩性改变中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Autoantibodies to the β(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction.

Autoantibodies to the β(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction.

Autoantibodies to the β(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction.

Autoantibodies to the β(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction.

The presence of serum autoantibodies in periodontitis (P) patients against β(1)-adrenoceptor (β(1)-AR), using cardiac membranes or a synthetic β(1)-AR peptide corresponding to the second extracellular loop of human β(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-β(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-β(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the β(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-β(1)-AR autoantibodies in alteration of myocardial contractility.

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