{"title":"牙周炎患者β(1)-肾上腺素能受体自身抗体是心功能障碍的危险因素","authors":"Marcela Segovia, Silvia Reina, Enri Borda, Leonor Sterin-Borda","doi":"10.5402/2011/791393","DOIUrl":null,"url":null,"abstract":"<p><p>The presence of serum autoantibodies in periodontitis (P) patients against β(1)-adrenoceptor (β(1)-AR), using cardiac membranes or a synthetic β(1)-AR peptide corresponding to the second extracellular loop of human β(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-β(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-β(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the β(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-β(1)-AR autoantibodies in alteration of myocardial contractility.</p>","PeriodicalId":89396,"journal":{"name":"ISRN dentistry","volume":"2011 ","pages":"791393"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170702/pdf/","citationCount":"9","resultStr":"{\"title\":\"Autoantibodies to the β(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction.\",\"authors\":\"Marcela Segovia, Silvia Reina, Enri Borda, Leonor Sterin-Borda\",\"doi\":\"10.5402/2011/791393\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The presence of serum autoantibodies in periodontitis (P) patients against β(1)-adrenoceptor (β(1)-AR), using cardiac membranes or a synthetic β(1)-AR peptide corresponding to the second extracellular loop of human β(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-β(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-β(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the β(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-β(1)-AR autoantibodies in alteration of myocardial contractility.</p>\",\"PeriodicalId\":89396,\"journal\":{\"name\":\"ISRN dentistry\",\"volume\":\"2011 \",\"pages\":\"791393\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170702/pdf/\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ISRN dentistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5402/2011/791393\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2011/9/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ISRN dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5402/2011/791393","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/9/7 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Autoantibodies to the β(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction.
The presence of serum autoantibodies in periodontitis (P) patients against β(1)-adrenoceptor (β(1)-AR), using cardiac membranes or a synthetic β(1)-AR peptide corresponding to the second extracellular loop of human β(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-β(1)-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-β(1)-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the β(1)-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-β(1)-AR autoantibodies in alteration of myocardial contractility.