衰老的免疫系统及其与癌症的关系。

Aging health Pub Date : 2011-10-01 DOI:10.2217/ahe.11.56

Anthony D Foster, Amogh Sivarapatna, Ronald E Gress

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引用次数: 82

摘要

大多数常见癌症的发病率随着年龄的增长而增加。这种情况与免疫功能下降有关，并可能由免疫功能下降引起，称为免疫衰老。尽管t细胞区室的大小在数量上维持到老年，但随着时间的推移，会发生一些有害的变化(包括t细胞亚群的显著变化)，从而显著损害免疫力。这篇文章强调了一些关于衰老免疫系统的最新发现，重点是t细胞区室及其在癌症中的作用。

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The aging immune system and its relationship with cancer.

The incidence of most common cancers increases with age. This occurs in association with, and is possibly caused by a decline in immune function, termed immune senescence. Although the size of the T-cell compartment is quantitatively maintained into older age, several deleterious changes (including significant changes to T-cell subsets) occur over time that significantly impair immunity. This article highlights some of the recent findings regarding the aging immune system, with an emphasis on the T-cell compartment and its role in cancer.

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来源期刊

Aging health

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